Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P

The Journal of Immunology : Official Journal of the American Association of Immunologists
Tom BosschaertsAlain Beschin

Abstract

Uncontrolled inflammation is a major cause of tissue injury/pathogenicity often resulting in death of a host infected with African trypanosomes. Thus, comparing the immune response in hosts that develop different degrees of disease severity represents a promising approach to discover processes contributing to trypanosomiasis control. It is known that limitation of pathogenicity requires a transition in the course of infection, from an IFN-gamma-dependent response resulting in the development of classically activated myeloid cells (M1), to a counterbalancing IL-10-dependent response associated with alternatively activated myeloid cells (M2). Herein, mechanisms and downstream effectors by which M2 contribute to lower the pathogenicity and the associated susceptibility to African trypanosomiasis have been explored. Gene expression analysis in IL-10 knockout and wild-type mice, that are susceptible and relatively resistant to Trypanosoma congolense infection, respectively, revealed a number of IL-10-inducible genes expressed by M2, including Sepp1 coding for selenoprotein P. Functional analyses confirm that selenoprotein P contributes to limit disease severity through anti-oxidant activity. Indeed, Sepp1 knockout mice, but not Sepp...Continue Reading

References

Apr 1, 1989·Parasitology·P VincendeauB Veyret
Dec 1, 1970·Experimental Parasitology·S M Lanham, D G Godfrey
Jun 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·I DreherJ Köhrle
Jul 1, 1997·Histochemistry and Cell Biology·R F BurkH S Chittum
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F BurkM E Boeglin
Jun 25, 1998·Revue Scientifique Et Technique·G D d'IeterenM Murray
Mar 22, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·H TabelJ Uzonna
May 5, 2000·Digestive Diseases and Sciences·G D'ArgenioP D Bishop
Aug 2, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F IraqiA J Teale
Dec 13, 2000·Microbes and Infection·H TabelJ E Uzonna
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·M P Moschos
Mar 30, 2001·The Journal of Biological Chemistry·R J HondalR F Burk
Oct 31, 2001·Public Health Nutrition·K M Brown, J R Arthur
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HesseT A Wynn
Mar 29, 2002·Arthritis and Rheumatism·Wu-Shiun HouDieter Brömme
Feb 8, 2003·The Journal of Biological Chemistry·Kristina E HillRaymond F Burk
Feb 21, 2003·European Journal of Immunology·Meiqing ShiHenry Tabel
May 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jacek BaniaPhilippe Pierre
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·O HanotteA Teale
Jan 6, 2004·The Journal of Nutrition·Kristina E HillRaymond F Burk
Mar 24, 2004·Trends in Parasitology·Wim NoëlAlain Beschin
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Shin-Ichiro MaeharaYoshihiko Maehara
Mar 4, 2005·Biology of Reproduction·Gary E OlsonRaymond F Burk
Apr 6, 2005·Veterinary Immunology and Immunopathology·Emmeline W HillDavid E MacHugh
Apr 27, 2005·Nutrition·Akira AndohYoshihide Fujiyama
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lea BrysPatrick De Baetselier
May 17, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David CourtinAndré Garcia

❮ Previous
Next ❯

Citations

Mar 6, 2013·The Journal of Biological Chemistry·Rachel H McMahanHugo R Rosen
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin GuilliamsAlain Beschin
Jul 17, 2008·The Journal of Infectious Diseases·Martin GuilliamsAlain Beschin
Jan 21, 2010·Infection and Immunity·Liam J MorrisonC Michael R Turner
Dec 4, 2009·PLoS Neglected Tropical Diseases·Liam J MorrisonAnnette MacLeod
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graziella SolinasPaola Allavena
Feb 26, 2011·The Journal of Parasitology·Kazuhiko NishimuraShinji Yamasaki
Apr 4, 2014·Inflammatory Bowel Diseases·Bodo Speckmann, Holger Steinbrenner
May 14, 2014·BioMed Research International·Judith Pacheco-YepezRafael Campos-Rodriguez
Jun 20, 2015·BioMed Research International·Benoit StijlemansPatrick De Baetselier
May 15, 2015·Annual Review of Nutrition·Raymond F Burk, Kristina E Hill
Jun 18, 2016·Molecular & Cellular Oncology·Sarah P ShortChristopher S Williams
May 20, 2020·Frontiers in Oncology·Marina SerraAlessio Menga
Apr 3, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sajad RashidiGholamreza Hatam
Apr 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marina V KasaikinaVadim N Gladyshev
Jan 10, 2013·Annual Review of Immunology·Steven J Van Dyken, Richard M Locksley
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V De WildeA Le Moine
Apr 29, 2009·Cellular and Molecular Life Sciences : CMLS·M A Reeves, P R Hoffmann
Jun 9, 2015·The Journal of Clinical Investigation·Caitlyn W BarrettChristopher S Williams
Sep 16, 2016·PLoS Pathogens·Benoît StijlemansPatrick De Baetselier
Jan 31, 2020·Critical Reviews in Biochemistry and Molecular Biology·Fenghua QianK Sandeep Prabhu
Jul 14, 2012·Journal of Parasitology Research·Elisama AzevedoVerônica P Salerno
Mar 10, 2009·Biochimica Et Biophysica Acta·Holger Steinbrenner, Helmut Sies
Apr 7, 2009·Biochimica Et Biophysica Acta·Raymond F Burk, Kristina E Hill
Jul 8, 2010·Immunobiology·Ann VankrunkelsvenBenoît Stijlemans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis