Alternatively spliced isoforms of the Na+/Ca2+ exchanger in the guinea pig cochlea

Biochemical and Biophysical Research Communications
T OshimaT Takasaka

Abstract

The cochlea has been suggested to express some Na+/ Ca2+ exchangers (NCX), since efficient acoustic transduction requires cytosolic calcium homeostasis. The present study revealed that several spliced isoforms of NCX are expressed in the guinea pig cochlea. Moreover, to determine their localization in the cochlea, microdissected RT-PCR was performed. The guinea pig cochlea was microdissected into three parts (lateral wall, the organ of Corti and modiolus). The cochlear lateral wall and the organ of Corti expressed only a single isoform of NCX1. On the other hand, five isoforms of NCX1 and four isoforms of NCX3 were detected in the cochlear modiolus. The alternative splicing may provide diverse functions for NCX in the cochlea.

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Citations

Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Shun-Ichi Imamura, Joe C Adams
Jan 24, 2004·The Tohoku Journal of Experimental Medicine·Katsuhisa Ikeda
Aug 17, 2005·Cell Calcium·Danilo GueriniErnesto Carafoli
Jun 28, 2016·Pflügers Archiv : European journal of physiology·Takamasa YoshidaHiroshi Hibino
Jun 30, 2018·Physiological Genomics·Janet L Fitzakerley, George J Trachte
Apr 30, 2010·Journal of Physiology and Biochemistry·Paola Algara-SuárezRicardo Espinosa-Tanguma
Jul 21, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·K WakimotoY Nabeshima
Jun 30, 2000·Biochemical and Biophysical Research Communications·T OshimaT Takasaka

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