Alternatives to antibiotics-a pipeline portfolio review

The Lancet Infectious Diseases
Lloyd CzaplewskiJohn H Rex

Abstract

Antibiotics have saved countless lives and enabled the development of modern medicine over the past 70 years. However, it is clear that the success of antibiotics might only have been temporary and we now expect a long-term and perhaps never-ending challenge to find new therapies to combat antibiotic-resistant bacteria. A broader approach to address bacterial infection is needed. In this Review, we discuss alternatives to antibiotics, which we defined as non-compound approaches (products other than classic antibacterial agents) that target bacteria or any approaches that target the host. The most advanced approaches are antibodies, probiotics, and vaccines in phase 2 and phase 3 trials. This first wave of alternatives to antibiotics will probably best serve as adjunctive or preventive therapies, which suggests that conventional antibiotics are still needed. Funding of more than £1·5 billion is needed over 10 years to test and develop these alternatives to antibiotics. Investment needs to be partnered with translational expertise and targeted to support the validation of these approaches in phase 2 trials, which would be a catalyst for active engagement and investment by the pharmaceutical and biotechnology industry. Only a sust...Continue Reading

References

Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Anne Bruttin, Harald Brüssow
Jul 16, 2005·Current Eye Research·Y Jerold GordonAlison M McDermott
Jun 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rubhana RaqibBirgitta Agerberth
Dec 13, 2006·Nature Reviews. Drug Discovery·David J PayneDavid L Pompliano
Jan 11, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·UNKNOWN American Burn Association/American College of Surgeons
Mar 27, 2007·Nature Biotechnology·Monisha G ScottRobert E W Hancock
May 1, 2007·Trends in Immunology·Kelly L BrownRobert E W Hancock
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Timothy K Lu, James J Collins
Jan 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael McArthur, Mervyn J Bibb
Oct 11, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S I AguiarUNKNOWN Portuguese Surveillance Group for the Study of Respiratory Pathogens
Nov 27, 2008·Journal of Evolutionary Biology·A D MorganA Buckling
Jan 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Sophie Moreau-MarquisBruce A Stanton
Mar 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stan Deresinski
Jun 19, 2009·Drug News & Perspectives·Heather Fairhead
Aug 14, 2009·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·A WrightD R Harper
Sep 9, 2009·BMC Medicine·Walter J F M van der VeldenJ Peter Donnelly
Sep 10, 2009·Antimicrobial Agents and Chemotherapy·Karoline Sidelmann BrinchHans-Henrik Kristensen
Dec 30, 2009·Journal of Pharmaceutical Sciences·Oliver GhobrialJeffrey D Hillman
Feb 5, 2010·Clinical Pharmacology and Therapeutics·J A DiMasiA Wilson
Feb 20, 2010·Science·Nityakalyani SrinivasJohn A Robinson
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Danilo Gomes MorielLaura Serino
May 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Annalisa NuccitelliC Daniela Rinaudo
Dec 14, 2011·The Journal of Infectious Diseases·Lee M HamptonMatthew Moore
Jan 27, 2012·Biology Letters·Michelle G J L Habets, Michael A Brockhurst
Feb 11, 2012·Nature Reviews. Drug Discovery·Dan Jones
Feb 16, 2012·Bacteriophage·Stephen T AbedonElizabeth Martin Kutter
Mar 17, 2012·Nature Reviews. Microbiology·Robert E W HancockDana J Philpott
Mar 27, 2012·Trends in Microbiology·Julia J Williams, Paul J Hergenrother
Mar 30, 2012·The Journal of Infectious Diseases·Mathieu BangertAras Kadioglu
Aug 4, 2012·International Journal of Antimicrobial Agents·Katerina Kotzampassi, Evangelos J Giamarellos-Bourboulis
Aug 14, 2012·EMBO Molecular Medicine·Ian TeoSunil Shaunak
Dec 13, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ayumi YoshizumiKazuhiro Tateda
May 10, 2013·Nature Biotechnology·Jeffrey L Fox
Jul 25, 2013·Current Opinion in Microbiology·César de la Fuente-NúñezRobert E W Hancock
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Louise MatthewsStuart W J Reid
Sep 27, 2013·Current Topics in Medicinal Chemistry·Roberta CozziIlaria Ferlenghi
Nov 16, 2013·Nature Chemical Biology·Ashley L HilchieRobert E W Hancock

❮ Previous
Next ❯

Citations

Apr 2, 2016·Intensive Care Medicine·Bruno FrançoisMarc Bonten
Apr 20, 2016·Intensive Care Medicine·Kevin B LauplandStephan Harbarth
Apr 20, 2016·Intensive Care Medicine·George DimopoulosJon Cohen
Mar 31, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan R HauserDonald T Moir
Apr 22, 2016·Expert Review of Vaccines·Alejandro Cabezas CruzJosé de la Fuente
May 23, 2016·The Lancet Infectious Diseases·Laura J V Piddock
Aug 31, 2016·Nature Microbiology·Carolyn K Shore, Allan Coukell
May 14, 2016·Expert Opinion on Drug Discovery·Alastair L Parkes, Ian A Yule
Jun 9, 2016·Trends in Pharmacological Sciences·Mark G Moloney
Oct 19, 2016·Current Opinion in Microbiology·Damien MauraLaurence G Rahme
Jun 30, 2016·The Journal of Antibiotics·Mark S ButlerMatthew A Cooper
Oct 19, 2016·Current Opinion in Microbiology·Michael R Hamblin
Aug 20, 2016·Science·Ramanan LaxminarayanMark Woolhouse
Aug 21, 2016·Letters in Applied Microbiology·J S FranklyneN Chandrasekaran
Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cristina Prat, Alicia Lacoma
Nov 2, 2016·Journal of Pharmaceutical Policy and Practice·Ejike NwokoroJens Plahte
Oct 26, 2016·Expert Opinion on Drug Delivery·Elsa Bodier-MontagutelliNathalie Heuzé-Vourc'h
Nov 10, 2016·Expert Opinion on Therapeutic Patents·Pedro M S D CalGonçalo J L Bernardes
Sep 30, 2016·Expert Review of Clinical Pharmacology·Jordi RelloAntonio Perez
Mar 18, 2017·Expert Review of Anti-infective Therapy·Katherine H Luepke, John F Mohr
Mar 8, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T M RawsonA H Holmes
Mar 25, 2017·Age and Ageing·Victoria EwanJohn Simpson
Jan 22, 2017·Journal of Biotechnology·Szymon P SzafrańskiMeike Stiesch
Mar 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rensen RanXia Xu
Mar 23, 2017·The Journal of Infectious Diseases·Joanna JammalAmram Mor
Mar 7, 2017·Scientific Reports·Kenneth ShatzkesDaniel E Kadouri
Jun 27, 2017·Nature Reviews. Microbiology·Jeroen De SmetRob Lavigne
Jun 13, 2017·Nature Reviews. Microbiology·Hilary P BrowneTrevor D Lawley
Jun 28, 2017·The Lancet Infectious Diseases·Ibrahim Abubakar, Helen Strain
Aug 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MolchanovaHenrik Franzyk
Nov 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunlan XuMingliang Jin
Mar 30, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Florian Kloß, Sina Gerbach
Feb 28, 2018·Frontiers in Veterinary Science·Delphine Destoumieux-GarzónYann Voituron
Sep 28, 2017·Expert Opinion on Investigational Drugs·Adamantia LiapikouAntoni Torres
Dec 8, 2017·NPJ Biofilms and Microbiomes·Linda B OyamaSharon A Huws
Dec 1, 2017·Scientific Reports·Noemí BustamanteMargarita Menéndez

❮ Previous
Next ❯

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