Alternatives to blood product transfusion in the critically ill: erythropoietin

Critical Care Medicine
James R Stubbs

Abstract

To present information regarding the use of recombinant human erythropoietin (rHuEPO) to treat anemia in intensive care unit (ICU) patients Anemia is common in critically ill patients. Approximately 95% of patients have subnormal hemoglobin (Hb) values by day 3 of their ICU stay. ICU-associated anemia often requires replacement of red blood cells (RBCs) via transfusion. Recent surveys of ICU practice document that approximately 50% of ICU patients receive RBC transfusions. ICU-associated anemia is largely the result of the cumulative effects of blood loss and decreased RBC production. Blood loss in critically ill patients may be overt, occult, or due to phlebotomy. Decreased RBC production is the other major factor influencing the development of anemia. Decreased RBC production is due to the combined effects of abnormal iron metabolism, inappropriately low erythropoietin production, diminished response to erythropoietin, and direct suppression of RBC production. Inflammatory mediators play a pivotal role in the pathogenesis of decreased RBC production. Clinical trials have shown that, compared with nontreated subjects, rHuEPO-treated ICU patients will have increased serum erythropoietin concentrations, increased reticulocyte co...Continue Reading

References

Jan 1, 1990·Kidney International·F StockenhuberK Lechner
May 8, 1986·The New England Journal of Medicine·B R Smoller, M S Kruskall
Sep 1, 1995·Chest·H L CorwinA Gettinger
Jan 1, 1994·The Journal of Burn Care & Rehabilitation·G P PoletesJ Lincks
May 1, 1994·The American Journal of the Medical Sciences·S B Krantz
May 1, 1994·Critical Care Medicine·B Krafte-JacobsM M Pollack
Nov 1, 1996·European Journal of Haematology·J AbelW Jelkmann
Feb 1, 1997·Intensive Care Medicine·P RogiersJ L Vincent
Aug 1, 1997·Intensive Care Medicine·J F NavarroD Fuchs
Sep 3, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W Jelkmann
Dec 2, 1999·Genes & Development·A BauerH Beug
Aug 31, 2000·Critical Care Medicine·H L Corwin, S B Krantz
May 25, 2001·Critical Care Medicine·P Hobisch-HagenW Schobersberger
Jul 28, 2001·Seminars in Hematology·R A Larson
Aug 28, 2001·Seminars in Hematology·H L Corwin
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Jean Louis VincentUNKNOWN ABC (Anemia and Blood Transfusion in Critical Care) Investigators
Dec 11, 2002·JAMA : the Journal of the American Medical Association·Howard L CorwinUNKNOWN EPO Critical Care Trials Group
Mar 9, 2005·Critical Care Medicine·Howard L Corwin, Paul Hebert
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Dimitris GeorgopoulosUNKNOWN Critical Care Clinical Trials Greek Group

❮ Previous
Next ❯

Citations

Mar 15, 2012·Journal of Clinical Anesthesia·Carolyn Hyatt Sherman, Duncan C Macivor
Sep 24, 2009·Critical Care Medicine·Lena M NapolitanoUNKNOWN Eastern Association for the Surgery of Trauma Practice Management Workgroup
Sep 22, 2007·Critical Care Medicine·Aryeh Shander, Mazyar Javidroozi
Oct 1, 2008·Pharmacotherapy·Kwame Asare
Aug 10, 2016·The Journal of Critical Care Medicine·Gautam RawalAmrita Singh
Apr 28, 2007·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S P StawickiM Lorenzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Howard L Corwin, Kai-Uwe Eckardt
The New England Journal of Medicine
Howard L CorwinEPO Critical Care Trials Group
© 2022 Meta ULC. All rights reserved