Altitude illness: update on prevention and treatment

Current Sports Medicine Reports
Richard P Eide, Chad A Asplund

Abstract

Altitude illness is a broad category of disease encompassing acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE) that can affect persons who travel to altitude without adequate acclimatization. Initial symptoms of AMS and the more serious HACE or HAPE can be subtle, and it is important that the practitioner be able to recognize and differentiate between these diagnoses because they can progress rapidly and be fatal if untreated. There are well-established criteria and many proven therapies both for prophylaxis and treatment of altitude illness; however, despite intense research efforts, the specific mechanisms of these complex diseases remain elusive. Adequate acclimatization via controlled ascent remains the most important factor in preventing altitude illness, although prophylactic pharmacotherapy also may be useful. Rapid descent remains the most important treatment factor, although treatment at altitude with various therapies is possible for mild cases with adequate resources.

References

Apr 24, 1993·BMJ : British Medical Journal·P BärtschO Oelz
Dec 16, 1998·JAMA : the Journal of the American Medical Association·P H HackettJ McCormick
Aug 7, 2008·Chest·Robert B Schoene
Mar 11, 2009·QJM : Monthly Journal of the Association of Physicians·J K BaillieD J Webb
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·James D WebbChristopher W Pugh
Sep 19, 2009·Cellular and Molecular Life Sciences : CMLS·Damian Miles BaileyRalf W Baumgartner

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Citations

Oct 16, 2014·Journal of Community Hospital Internal Medicine Perspectives·Anil PanditMadan R Aryal
Mar 6, 2015·Asian Journal of Sports Medicine·Haley RingwoodDarcy K Selenke
May 13, 2017·Current Sports Medicine Reports·Katherine V YaoWilliam O Roberts
Jul 1, 2018·The Cochrane Database of Systematic Reviews·Daniel Simancas-RacinesRicardo Hidalgo
May 28, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jia WangYun You Duan
Nov 17, 2020·Dose-response : a Publication of International Hormesis Society·Jiewen TanZhuo Li

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