Altitude-Induced Pulmonary Hypertension on One-Day Rapid Ascent of Mount Fuji: Incidence and Therapeutic Effects of Sildenafil

Echocardiography
Masatsugu IwaseYukio Ozaki

Abstract

Exposure to high altitudes especially with rapid ascent may induce hypoxic pulmonary vasoconstriction (HPV) and pulmonary hypertension (PH) possibly leading to life-threatening high-altitude pulmonary edema (HAPE). The aim of the study was to evaluate the incidence of PH on a 1-day rapid ascent up Mount Fuji (3775 m) in recreational climbers and also to determine the effectiveness of sildenafil for this rapid ascent-induced PH as measured by echocardiography. Twenty-five subjects who climbed Mount Fuji showed significantly increased pulmonary artery systolic pressure (PASP) from 22.3 ± 5.3 mmHg at sea level to 29.4 ± 8.7 mmHg at 3775 m. Five subjects showed PASP >35 mmHg (35.6-46.2 mmHg, average 42.0 ± 3.9 mmHg) and took oral sildenafil 50 mg after which PASP decreased significantly to 24.5 ± 4.6 mmHg (18.7-31.0 mmHg) after 30 minutes. One-day rapid ascent of Mount Fuji may induce mild-to-moderate PH and intervention with sildenafil can reduce this PH, suggesting that the therapeutic use of sildenafil would be more reasonable for the relatively infrequent occurrence of altitude-induced PH than its prophylactic use.

References

Oct 31, 1991·The New England Journal of Medicine·P BärtschO Oelz
Oct 13, 1990·BMJ : British Medical Journal·M MaggioriniO Oelz
Aug 1, 1996·Journal of Applied Physiology·M W EldridgeJ W Severinghaus
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y AllemannM Maggiorini
May 1, 2002·JAMA : the Journal of the American Medical Association·Erik R SwensonPeter Bärtsch
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Jean-Paul RichaletJérémy Cornolo
Nov 3, 2006·The European Respiratory Journal·B K KojonazarovA A Aldashev
Jun 23, 2007·High Altitude Medicine & Biology·Peter J FagenholzN Stuart Harris
Dec 14, 2007·Wilderness & Environmental Medicine·Gerald Dubowitz, Andrew J Peacock
Mar 24, 2012·Wilderness & Environmental Medicine·Rajesh DeshwalSidhant Basnet
Nov 13, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eduardo BossoneRobert Naeije
Jun 14, 2013·The New England Journal of Medicine·Peter Bärtsch, Erik R Swenson

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Citations

Nov 15, 2017·Current Sports Medicine Reports·Luigi Di LuigiStefania Sabatini
Sep 30, 2016·Echocardiography·Masatsugu Iwase

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