Alum-precipitated autoclaved Leishmania major plus bacille Calmette-Guérrin, a candidate vaccine for visceral leishmaniasis: safety, skin-delayed type hypersensitivity response and dose finding in healthy volunteers

Transactions of the Royal Society of Tropical Medicine and Hygiene
A A KamilAhmed Mohamed El-Hassan

Abstract

In a previous efficacy study, autoclaved Leishmania major (ALM) + bacille Calmette-Guérrin (BCG) vaccine was shown to be safe, but not superior to BCG alone, in protecting against visceral leishmaniasis. From June 1999 to June 2000, we studied the safety and immunogenicity of different doses of alum-precipitated ALM + BCG vaccine mixture administered intradermally to evaluate whether the addition of alum improved the immunogenicity of ALM. Twenty-four healthy adult volunteers were recruited and sequentially allocated to receive either 10 microg, 100 microg, 200 microg, or 400 microg of leishmanial protein in the alum-precipitated ALM + BCG vaccine mixture. Side effects were minimal for all doses and confined to the site of injection. All volunteers in the 10 microg, 100 microg, and 400 microg groups had a leishmanin skin test (LST) reaction of > or = 5 mm by day 42 and this response was maintained when tested after 90 d. Only 1 volunteer out of 5 in the 200 microg group had a LST reaction of > or = 5 mm by day 42 and the reasons for the different LST responses in this group are unclear. This is the first time that an alum adjuvant with ALM has been in used in humans and the vaccine mixture was safe and induced a strong delayed ...Continue Reading

References

Nov 1, 1977·Infection and Immunity·L L Smrkovski, C L Larson
Apr 1, 1992·The American Journal of Tropical Medicine and Hygiene·J A KurtzhalsA Kharazmi
Dec 1, 1986·The Journal of Infectious Diseases·R BadaroW D Johnson
Jun 1, 1994·Journal of Clinical Pathology·I A el HagA M el Hassan
Jul 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M el-HassanE E Zijlstra
Jul 1, 1993·The Journal of Clinical Investigation·H W GhalibS G Reed
Jan 1, 1993·Vaccine·R K GuptaC K Gupta
Nov 22, 2000·Archives of Disease in Childhood·M GonzalezH Picolet
Feb 1, 1988·Parasitology Today·C L Greenblatt

❮ Previous
Next ❯

Citations

Oct 30, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ahmed Mudawi MusaUNKNOWN Leishmaniasis Research Group/Sudan
Feb 6, 2007·Parasitology·L KedzierskiE Handman
Aug 21, 2007·Kinetoplastid Biology and Disease·Hashim Ghalib, Farrokh Modabber
Jul 22, 2005·PLoS Medicine·Asrat HailuMonique Wasunna
Dec 17, 2014·Clinical & Translational Immunology·Rajiv Kumar, Christian Engwerda
Jul 2, 2008·Expert Opinion on Drug Delivery·Sudipta Bhowmick, Nahid Ali
May 2, 2013·Journal of Tropical Medicine·Eltahir Awad Gasim KhalilAhmed Mohamed El-Hassan
Apr 11, 2015·Journal of Immunological Methods·Keerti Jain, N K Jain
Aug 28, 2012·Human Vaccines & Immunotherapeutics·Mona E E ElfakiAhmed M El-Hassan
May 28, 2011·International Immunopharmacology·Rajeev Nagill, Sukhbir Kaur
Jul 9, 2005·Microbes and Infection·Katrin KuhlsGabriele Schönian
Mar 1, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·Joshua M MutisoMichael M Gicheru
May 14, 2010·Revista Do Instituto De Medicina Tropical De São Paulo·Joshua M MutisoEvans Taracha
Apr 6, 2005·Clinical and Experimental Immunology·E A G KhalilA M Elhassan
Oct 30, 2016·Parasite Immunology·M BagirovaB Ergenoglu
Jan 10, 2020·Expert Opinion on Drug Delivery·Anis AskarizadehAli Khamesipour
Jan 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ranadhir DeyHira L Nakhasi
Aug 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ranadhir DeyHira L Nakhasi
Mar 27, 2020·Frontiers in Immunology·Clarisa Beatriz Palatnik-de-Sousa, Dirlei Nico

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.