PMID: 8943754Oct 1, 1996Paper

Aluminium and injection site reactions

Journal of Clinical Pathology
G A CuloraJ M Theaker

Abstract

To alert pathologists to the spectrum of histological appearances that may be seen in injection site reactions related to aluminium. Four cases of injection site reaction were examined microscopically using routine staining with haematoxylin and eosin, electron microscopy and by electron probe microanalysis. As in previous reports, all four cases included collections of histiocytes which contained faint granular brownish refractile material within their cytoplasm; ultrastructural examination showed this to be aluminium. Two cases showed a prominent inflammatory reaction with numerous lymphoid follicles and a notable eosinophilic infiltrate. Two cases showed unusual features not described previously. In one, there was a sclerosing lipogranuloma-like reaction with unlined cystic spaces containing crystalline material. The other case presented as a large symptomatic subcutaneous swelling which microscopically showed diffuse and wide-spread involvement of the subcutis by a lymphoid infiltrate with prominent lymphoid follicles. This report highlights the changes encountered in aluminium injection site reactions and emphasises that the lesions have a wider range of histological appearances than described previously.

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Citations

Jan 27, 2004·Vaccine·Edward RothsteinUNKNOWN Brighton Collaboration Local Reaction Working Group
Sep 18, 2003·Ophthalmology·Ari D AbelDale R Meyer
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Dec 16, 2006·BMJ : British Medical Journal·Jeffrey K Aronson, Manfred Hauben
Mar 25, 2008·Actas dermo-sifiliográficas·I HernándezA Alfaro
Aug 5, 2008·Annales de pathologie·Sabrina CroceMarie-Pierre Chenard
May 27, 2005·Vaccine·S ValtuliniH Morvan
Aug 24, 2013·International Immunopharmacology·Alexander Batista-DuharteOliver Pérez
Apr 3, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N N Al-SulimanM Bak
Sep 8, 2016·International Journal of Trichology·Kajal Manchanda, Sandip Mohanty
Nov 18, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benoit BusserLucie Sancey
Aug 19, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Manfred Hauben, Jeffrey K Aronson
Apr 23, 2021·Actas dermo-sifiliográficas·J Aróstegui AguilarA Fernandez-Flores
Jan 20, 2021·ACS Biomaterials Science & Engineering·Sean M KellyBalaji Narasimhan

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