Aluminium hydroxide down-regulates T helper 2 responses by allergen-stimulated human peripheral blood mononuclear cells

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L K WilcockS R Durham

Abstract

Aluminium hydroxide (alum) is a commonly used adjuvant for specific immunotherapy of allergic diseases. While alum is traditionally associated with murine Th2 sensitization, little is known about its effects on secondary allergic responses in humans. We investigated the in vitro effects of alum on peripheral blood mononuclear cells (PBMC) from atopic donors. PBMC from 18 grass pollen-sensitive rhinitic subjects were stimulated with Phleum pratense (Phl p) in the presence or absence of alum. After 6 days culture, cytokine production was measured by ELISA and T cell proliferation by radiolabelled thymidine incorporation. The effect of alum on the expression of human leucocyte antigen and CD80/CD86 on cultured antigen-presenting cells was assessed by flow cytometry. PBMC cultured with Phl p and alum showed a significant decrease in both IL-5 and IL-13 production compared with allergen alone (P<0.005 and P<0.001, respectively), but no change in IFN-gamma or IL-12 production or proliferative responses. These alum-induced changes in T helper (Th)2 cytokine production were unaffected by the addition of neutralizing antibodies to IL-4 or IL-12. Culture of PBMC with alum induced increased expression of CD86 (P=0.004) and HLA (P=0.01) on...Continue Reading

References

Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S R DurhamA B Kay
Jul 1, 1987·European Journal of Immunology·A TelermanR Mosselmans
Apr 1, 1997·International Immunology·E E ComoyG Thyphronitis
Feb 1, 1997·Vaccine·J C Cox, A R Coulter
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·S R Durham, S J Till
Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J BousquetH Yssel
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S R Durham
Aug 12, 1999·The New England Journal of Medicine·S R DurhamK T Nouri-Aria
Jun 6, 2000·Advanced Drug Delivery Reviews·R K Gupta
Jul 19, 2000·Current Opinion in Immunology·V E Schijns
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E M VargaS R Durham
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·S M WalkerS R Durham
Aug 20, 2002·Vaccine·C J Clements, E Griffiths
Aug 28, 2002·Immunity·Alison V CollinsSimon J Davis
Jun 6, 2003·The Journal of Allergy and Clinical Immunology·James N FrancisStephen R Durham
Jun 18, 2003·Trends in Immunology·David M SansomYong Zheng
Jul 1, 1942·American Journal of Public Health and the Nation's Health·V K Volk, W E Bunney

❮ Previous
Next ❯

Citations

Dec 3, 2008·Journal of Physiology and Biochemistry·N LukanI Tkac
Aug 6, 2013·Immunology Letters·Elke FuertbauerHannes Stockinger
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Jun 15, 2005·ILAR Journal·Kenneth C McCullough, Artur Summerfield
Sep 22, 2006·Annual Review of Medicine·E William St ClairJeffrey Bluestone
Jul 15, 2011·Immunotherapy·Stephan Deifl, Barbara Bohle
Jun 12, 2013·Expert Review of Vaccines·Zahra AryanNima Rezaei
May 3, 2013·Expert Review of Clinical Immunology·Ludger Klimek, Oliver Pfaar
May 3, 2011·Immunology and Allergy Clinics of North America·Philippe MoingeonLaurent Mascarell
Apr 10, 2007·The Journal of Allergy and Clinical Immunology·Giovanni PassalacquaUNKNOWN Global Allergy and Asthma European Network
Dec 1, 2015·Immunology and Allergy Clinics of North America·Julie ChesnéJulia Esser von-Bieren
Feb 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G SentiT M Kündig
Dec 24, 2010·Clinical and Experimental Immunology·M T Krishna, A P Huissoon
Aug 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S M WalkerUNKNOWN British Society for Allergy and Clinical Immunology
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Charlotte N MaughanGareth R Williams
Feb 18, 2014·Clinical and Experimental Immunology·B HeydenreichJ Saloga
Oct 26, 2012·Human Vaccines & Immunotherapeutics·Philippe Moingeon
Oct 18, 2006·Journal of Korean Medical Science·Young-Min YeHae-Sim Park
Apr 23, 2010·Current Opinion in Allergy and Clinical Immunology·M Beatrice BilòFloriano Bonifazi
Oct 24, 2012·Current Opinion in Allergy and Clinical Immunology·Oliver PfaarMoises A Calderon
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
May 29, 2013·American Journal of Rhinology & Allergy·Ludger KlimekJoerg Willers
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·James N Francis, Stephen R Durham
Feb 23, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Phornsiri Pechsrichuang, Alain Jacquet
Aug 22, 2017·Human Vaccines & Immunotherapeutics·Carlos GamazoJuan M Irache
Jul 14, 2020·Journal of Cellular Physiology·Zhongtao FengJafar Hajavi
Nov 27, 2019·Current Allergy and Asthma Reports·Mary Grace Baker, Julie Wang
Dec 8, 2020·Frontiers in Immunology·Max E KirtlandMohamed H Shamji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.