Aluminum: A potentially toxic metal with dose-dependent effects on cardiac bioaccumulation, mineral distribution, DNA oxidation and microstructural remodeling

Environmental Pollution
Rômulo D NovaesMariana Machado-Neves

Abstract

Large amounts of aluminum (Al) are found in wastewater from industrial bauxite mining, which is often responsible for the contamination of drinking water sources in urban and rural communities. Although this metal exhibits broad environmental distribution, its cardiac repercussions are poorly understood, making it difficult to establish diagnostic criteria in cases of Al intoxication. In the absence of clinical data, we used a preclinical model to investigate the impact of Al exposure on heart bioaccumulation, molecular oxidation, micromineral distribution, structural and ultrastructural remodeling of the cardiac tissue. Male Wistar rats were equally randomized into five groups: G1 = distilled water; and G2 to G5 = 0.02, 0.1, 50, and 200 mg/kg aluminum solution, respectively. After 120 days, the hearts were collected and subjected to mineral microanalysis, immunoenzymatic detection of 8-OHdG, as well as bright field, polarizing, scanning and transmission electron microscopy to estimate the extent of the cardiac remodeling and cardiomyocytes ultrastructure. Long-term Al exposure induced dose-dependent bioaccumulation, micromineral imbalance, genomic DNA oxidation, structural and ultrastructural abnormalities of the cardiac tissu...Continue Reading

Citations

Feb 19, 2020·Experimental Lung Research·Erika Tiemi KozimaFrank Silva Bezerra
Oct 28, 2019·Biological Trace Element Research·Luiz Carlos Maia LadeiraIzabel Regina Dos Santos Costa Maldonado
Jan 6, 2021·Biological Trace Element Research·Viviane Gorete Silveira MouroSérgio Luis Pinto da Matta
Feb 27, 2021·Biological Trace Element Research·LiuFang ZhouXi Wei
Jul 28, 2020·Life Sciences·Ana Cláudia Ferreira SouzaMariana Machado-Neves
Jul 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Menglin LiuYanfei Li
Jan 29, 2022·Pharmacological Reports : PR·Mangaldeep Dey, Rakesh Kumar Singh

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