Aluminum citrate is transported from brain into blood via the monocarboxylic acid transporter located at the blood-brain barrier

Toxicology
D C Ackley, R A Yokel

Abstract

Aluminum citrate transport across the blood-brain barrier was assessed in rats by in vivo microdialysis. Microdialysis probes were implanted in the jugular vein as well as the left and right frontal cortex. It was demonstrated previously (Allen et al., 1995), in this study, that the steady-state aluminum citrate brain-to-blood-ratio (BBr) is less than 1, suggesting the presence of a process other than diffusion. The addition of 2,4-dinitrophenol (10 microM) to the dialysate perfusing a microdialysis probe in the brain increased the steady-state aluminum citrate brain-to-blood-ratio to a value (1.14) not significantly different from 1, suggesting the presence of an active transporter that is blocked by the metabolic inhibitor. The addition of valproic and pyruvic acid, as putative and known substrates for the monocarboxylic acid transporter, respectively, to brain dialysate (10 and 100 mM) had different outcomes. Valproic acid was ineffective at either concentration, whereas pyruvic acid (100 mM) significantly increased the aluminum citrate brain-to-blood-ratio from 0.19 to 0.31. Pyruvic acid (1 M in the dialysate) increased the aluminum citrate brain-to-blood-ratio to a value not different from unity, suggesting competition bet...Continue Reading

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Citations

Feb 14, 2012·Biological Trace Element Research·Xin WuZe-Yuan Deng
Dec 28, 1999·Journal of Inorganic Biochemistry·R A YokelD C Ackley
Jul 27, 2001·Journal of Pharmaceutical and Biomedical Analysis·T B PolakM Benedik
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Apr 20, 1999·The Journal of Clinical Investigation·X ChenM A Hediger
Nov 12, 2002·Environmental Health Perspectives·Robert A Yokel
Aug 8, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hye-Ryoung KimHo-Chul Shin
Jan 21, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maria E MycielskaMustafa B A Djamgoz
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Yoshiharu Deguchi
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Sep 29, 1999·Ecotoxicology and Environmental Safety·M P SauvantJ Guillot
Sep 17, 2004·Journal of Toxicology and Environmental Health. Part a·Denis Bérubé
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
Apr 1, 2004·Clinical Science·David G ShirleyChristopher J Lote
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rongzi Yan, Eve M Taylor
Aug 10, 2021·Neurotoxicology·Daniela Silva-AdayaMaría E Gonsebatt

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