Aluminum disruption of calcium homeostasis and signal transduction resembles change that occurs in aging and Alzheimer's disease

Journal of Alzheimer's Disease : JAD
J R Walton

Abstract

Most humans living in industrialized societies are routinely exposed to bioavailable aluminum salts in the form of additives-in commercially-prepared foods, alum-clarified drinking water, certain pharmaceuticals, sunscreens, and other topical applications. Minute amounts of this aluminum are absorbed into the circulation. Trace aluminum levels cross the blood-brain barrier and progressively accumulate in large pyramidal neurons of the hippocampus, cortex, and other brain regions vulnerable in Alzheimer's disease. More aluminum enters the brain than leaves, resulting in a net increase in intraneuronal aluminum with advancing age. Aluminum is responsible for two main types of toxic damage in cells. As a pro-oxidant, aluminum causes oxidative damage both on its own and in synergy with iron. Aluminum also competes with, and substitutes for, essential metals-primarily Mg2+, iron and Ca2+ ions-in or on proteins and their co-factors. The author hypothesizes that intraneuronal aluminum interferes with Ca2+ metabolism in the aged brain and describes a way to test this hypothesis. This paper reviews: 1) major changes that occur in brain Ca2+ homeostasis and Ca2+ signaling, subtly with aging and more overtly in Alzheimer's disease; and 2)...Continue Reading

Citations

Mar 20, 2014·Metallomics : Integrated Biometal Science·Stefanie Pfaender, Andreas M Grabrucker
Jul 29, 2016·Immunologic Research·Shaye KivityYehuda Shoenfeld
Jan 17, 2014·Current Allergy and Asthma Reports·Brian J Balin, Alan P Hudson
Nov 28, 2014·International Journal of Molecular Sciences·Qiao LinJie Gao
Nov 10, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Neha Singla, D K Dhawan
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Caroline M TannerStephen J Grate
Mar 16, 2013·Phytotherapy Research : PTR·Ankica JelenkovićRajko Igić
Apr 9, 2016·Environmental Science and Pollution Research International·Samah S Oda
May 20, 2017·Environmental Science and Pollution Research International·Asmaa Fahmy Khafaga
Feb 20, 2013·Molecular Neurobiology·Neha Singla, D K Dhawan
Feb 14, 2018·International Journal of Molecular Medicine·Yin JiaAn-Mei Deng
Mar 4, 2019·Environmental Science and Pollution Research International·Madhavi TirumanyamJohn Sushma Nannepaga
Dec 3, 2016·Biological Trace Element Research·Maria L Reina de la TorreMiguel Navarro-Alarcón
Jul 18, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Changyu CaoKai Wang
Mar 17, 2021·Phytotherapy Research : PTR·Karim NarakiGholamreza Karimi
Jul 9, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Deniz Eren ErişenXiaolin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.