PMID: 9523861Apr 2, 1998Paper

Aluminum in total parenteral nutrition solutions produces portal inflammation in rats

Journal of Pediatric Gastroenterology and Nutrition
M DemircanG Ozok

Abstract

Aluminum contaminates parenteral nutrition solutions and accumulates in bone and liver of patients receiving total parenteral nutrition therapy. Although previous reports have shown that parenteral administration of aluminum in pharmacologic doses to rats results in the production of elevated total serum bile acid concentrations alone or in combination with decreased bile flow, they have failed to demonstrate any abnormalities in the histologic appearance of liver tissue. The effects of aluminum in total parenteral nutrition and of aluminum chloride on total serum bile acid concentrations, aluminum contents of the liver, and histopathologic changes in the liver were studied in rats. The aluminum concentrations in the aluminum chloride solution and total parenteral nutrition formula were equal (300 microg/l). They were given intraperitoneally as follows: control group, 0.9% saline for 14 days; T7 group, total parenteral nutrition for 7 days; A7 group, aluminum chloride for 7 days; A14 group, aluminum chloride for 14 days; T7A7 group, total parenteral nutrition for 7 days and aluminum chloride for the next 7 days; and T7O7 group, total parenteral nutrition for 7 days and 0.9% saline for the next 7 days. Volumes of 0.9% saline, al...Continue Reading

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Citations

Apr 4, 2002·Brain Research·Arezoo CampbellStephen C Bondy
Dec 28, 1999·Journal of Inorganic Biochemistry·G PérezA Nesse
Jul 27, 2001·Brain Research Bulletin·A CampbellG Perry
Dec 1, 2011·Food Additives & Contaminants. Part B, Surveillance·Gui-Fang DengHua-Bin Li
May 19, 2012·Journal of Pediatric Surgery·Abdulla AlemmariGord A Zello
Nov 3, 2010·Journal of the American Dietetic Association·Catherine J KleinLouis Scavo
Jul 19, 2002·Environmental Research·Prasunpriya Nayak
Jan 13, 2015·Cell Biochemistry and Biophysics·Yue SheYanfei Li
May 28, 2011·Journal of Pediatric Surgery·Abdulla AlemmariGordon A Zello
Apr 26, 2016·Journal of Pediatric Gastroenterology and Nutrition·Robert A Yokel, Jason M Unrine
Apr 8, 2004·Toxicology and Industrial Health·A BecariaS C Bondy
Mar 18, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Amanda R HallGordon A Zello
Apr 24, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mehmet DemircanBulent Mizrak

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