PMID: 8947945Nov 1, 1996Paper

Aluminum-induced neuropathology: transient changes in microtubule-associated proteins

Neurotoxicology and Teratology
N A Muma, S M Singer

Abstract

In susceptible species, aluminum induces cytoskeletal changes in which neurofilaments accumulate in neuronal cell bodies and proximal axonal enlargements. To determine if microtubule-associated proteins (MAPs) are altered in this model, we examined the spinal cords of aluminum- and saline-treated control rabbits at several time points after treatment. Transient decreases in tau and MAP2 immunoreactivity in neurons in aluminum-intoxicated rabbits were demonstrated with immunocytochemistry. An antibody directed against Alzheimer's disease paired helical filaments labeled neurons in aluminum-treated rabbits but not controls. MAP5 immunoreactivity in the cell body cytoplasm was displaced by aluminum-induced tangles. The transient decreases in MAP2 and tau immunoreactivity did not reflect alterations in protein levels measured using immunoblotting. The transient antigenic changes in tau and MAP2 may reflect conformational changes in these cytoskeletal proteins. Aluminum-induced pathology provides a model for studying perturbations in MAPs and neurofilament proteins that are characteristic of many human neurodegenerative diseases such as Alzheimer's disease, diffuse Lewy body disease, Parkinson's disease, and amyotrophic lateral scle...Continue Reading

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Oct 24, 2015·Brain Pathology·Ramesh KandimallaKiran Dip Gill
Mar 23, 2011·International Journal of Alzheimer's Disease·Masahiro Kawahara, Midori Kato-Negishi
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S MayaDivakar Goli
Jul 6, 2007·Expert Review of Neurotherapeutics·Remi DosunmuNasser H Zawia
Jun 13, 2017·Neuropathology and Applied Neurobiology·A KingC Exley
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna Dolar-SzczasnyJerzy Mackiewicz
May 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cezary GrochowskiPiotr Rzymski

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