Aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions

The New England Journal of Medicine
N J BishopA Lucas

Abstract

Aluminum, a contaminant of commercial intravenous-feeding solutions, is potentially neurotoxic. We investigated the effect of perinatal exposure to intravenous aluminum on the neurologic development of infants born prematurely. We randomly assigned 227 premature infants with gestational ages of less than 34 weeks and birth weights of less than 1850 g who required intravenous feeding before they could begin enteral feeding to receive either standard or specially constituted, aluminum-depleted intravenous-feeding solutions. The neurologic development of the 182 surviving infants who could be tested was assessed by using the Bayley Scales of Infant Development at 18 months of age. The 90 infants who received the standard feeding solutions had a mean (+/-SD) Bayley Mental Development Index of 95+/-22, as compared with 98+/-20 for the 92 infants who received the aluminum-depleted solutions (P=0.39). In a planned subgroup analysis of infants in whom the duration of intravenous feeding exceeded the median and who did not have neuromotor impairment, the mean values for the Bayley Mental Development Index for the 39 infants who received the standard solutions and the 41 infants who received the aluminum-depleted solutions were 92+/-20 a...Continue Reading

References

Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Mar 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·D BougleJ F Duhamel
Nov 1, 1986·The Journal of Clinical Investigation·P L MoseleyG W Hunninghake
Sep 1, 1989·Archives of Disease in Childhood·N J BishopM O'Hara
Sep 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·W W KooR Bendon
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·M R Wills, J Savory
Apr 1, 1989·Archives of Disease in Childhood·C Amiel-Tison, A Stewart
Nov 1, 1986·The Journal of Pediatrics·W W KooJ J Steichen
Jun 1, 1988·Journal of the American College of Nutrition·W W Koo, L A Kaplan
May 23, 1985·The New England Journal of Medicine·A B SedmanA C Alfrey
Nov 6, 1982·Lancet·B F BoyceI T Boyle
Nov 1, 1984·The Journal of Pediatrics·A B SedmanA C Alfrey
Nov 1, 1980·Acta paediatrica Scandinavica·E Nathan, S E Pedersen
Jan 1, 1994·Acta Paediatrica·A MorenoA Ballabriga

❮ Previous
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Citations

Sep 23, 2009·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·K WeisserB Keller-Stanislawski
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·P W GeisslerB Lowe
Sep 26, 2003·Journal of Inorganic Biochemistry·Sakae YumotoHiroyuki Matsuzaki
Jul 27, 2001·Brain Research Bulletin·S YumotoK Kobayashi
Feb 6, 2002·Nutrition·Patrick A Ball
Jan 26, 1999·Nutrition·P A Ball
Jan 15, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·D BohrerR Carlesso
Feb 14, 2013·European Journal of Clinical Nutrition·A Hernández-SánchezM Arteta-Jiménez
Nov 5, 1997·The New England Journal of Medicine·A I Gilbert, M F Graham
Mar 17, 2006·The New England Journal of Medicine·Raymund L YongGayatri M Sreenivasan
Oct 10, 1998·Archives of Environmental Health·S A McCurdy
May 31, 2003·Food Additives and Contaminants·I Navarro-Blasco, J I Alvarez-Galindo
Aug 26, 1998·Journal of the American College of Nutrition·T Canada, J Albrecht
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Mar 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Emmanuelle AdvenierOdile Corriol
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P Ball
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kentigern ThorburnPaul Baines
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kathleen M Gura, Mark Puder
Mar 8, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Mary Fewtrell
Sep 3, 2010·BMC Pediatrics·Shelle-Ann M Burrell, Christopher Exley
Aug 7, 2013·Journal of Inorganic Biochemistry·Marlei VeigaMauro S Oliveira
Nov 16, 2013·Environmental Science and Pollution Research International·Sohail EjazMuhammad Ashraf
Apr 8, 2010·Archives of Environmental Contamination and Toxicology·Daniela Dimer LeffaVanessa Moraes de Andrade
Nov 28, 2014·Immunotherapy·Christopher A ShawLucija Tomljenovic
Mar 19, 2014·Cell Biochemistry and Biophysics·Weijiang WuGuozhen Hui
Dec 23, 2011·Annals of Medicine·Lucija Tomljenovic, Christopher A Shaw
Nov 22, 2011·Journal of Inorganic Biochemistry·Lucija Tomljenovic, Christopher A Shaw
Mar 31, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tasneem G KaziAbdul Q Shah
Oct 18, 2015·Neurotoxicology and Teratology·William R MundyJohn Cowden
Dec 5, 2006·European Journal of Internal Medicine·Gerhard StoehrChristian Ohmann
Mar 1, 2006·Pharmacotherapy·Lara E StormsJames E Dice

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