Aluminum toxicity following intravesical alum irrigation for hemorrhagic cystitis

Medical and Pediatric Oncology
V S KanwarW L Furman

Abstract

Mental status changes in an immunosuppressed child can be due to a variety of causes; aluminum toxicity is rarely considered. We report a teenage girl with acute lymphoblastic leukemia who developed mental status changes, speech disturbance, coarse tremor, and abnormal EEG findings following intravesical 1% alum irrigation and administration of aluminum-containing antacids. Her serum aluminum levels were mildly elevated (14-22 milligram(s), normal 0-6 milligram(s)), and bone marrow biopsy specimens demonstrated aluminum deposition on special staining (Krueger's method). All abnormalities resolved after a nine-week course of intravenous deferoxamine.

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Citations

Mar 17, 2006·The New England Journal of Medicine·Raymund L YongGayatri M Sreenivasan
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marjorie S FriesenRobert D Gair
Mar 24, 2009·Journal of Pediatric Urology·Daniel B DeckerDuncan T Wilcox
Feb 6, 2015·Korean journal of pediatrics·Seung Beom HanJin Han Kang
Feb 7, 2008·Nature Clinical Practice. Urology·Ardeshir R RastinehadLouis R Kavoussi
Apr 29, 2016·Molecular and Clinical Oncology·Taito NakanoMikio Namiki

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