PMID: 2115072Aug 1, 1990Paper

Aluminum uptake by neuroblastoma cells

Journal of Neurochemistry
B Shi, A Haug

Abstract

Aluminum uptake studies in viable neuroblastoma cells were performed. Aluminum uptake was largely dependent on the pH of the suspension medium. At physiological pH values, cells were apparently unable to incorporate detectable amounts of aluminum in the absence of proper mediators. Aluminum uptake was enhanced as the pH decreased, attaining a plateau at about pH 6.0. In experiments with 2 x 10(6) cells/ml, pH 6.0, and 25 microM aluminum in the medium, aluminum incorporation reached saturation at 5 nmol of aluminum/mg of cellular protein, accounting for 60-70% of aluminum added. At pH 6.0, cells showed a large capacity for accumulating aluminum; about 70% of intracellular aluminum was associated with the postmitochondrial fraction. At neutral pH, application of apotransferrin seemed to facilitate aluminum translocation into cells via membrane receptors. Fatty acids were also capable of mediating aluminum uptake at neutral pH, probably by forming aluminum-fatty acid complexes. Low molecular weight aluminum chelators, e.g., citrate, inhibited aluminum uptake. Treatment of cells with energy metabolism blockers had virtually no influence on aluminum uptake, indicative of passive mechanisms. The results suggest that aluminum uptake o...Continue Reading

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Citations

Nov 15, 1996·Journal of Neuroscience Research·D NeillJ A Edwardson
Apr 21, 1993·Molecular and Cellular Biochemistry·B ShiA Haug
Jan 1, 1991·Biology of Metals·S J McGregorD Halls
Dec 1, 1994·Cellular and Molecular Neurobiology·I Farkas, L Erdélyi
Dec 1, 1994·Cellular and Molecular Neurobiology·B Platt, D Büsselberg
Jul 8, 2000·Metabolic Brain Disease·A SzutowiczH Bielarczyk
Aug 1, 1994·Molecular Neurobiology·R F Itzhaki
Jan 1, 1994·Archives of Toxicology·A HaugV Vitorello
Jan 1, 1993·Progress in Neurobiology·H MeiriA Rousseau
May 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H B JohnstonC K Atterwill
Jun 28, 2005·Biochimica Et Biophysica Acta·Christopher J L Silwood, Martin Grootveld
Jul 23, 1999·Brain Research·M B Suárez-FernándezM T Fernández-Sánchez
Jun 25, 1999·Free Radical Biology & Medicine·A CampbellS C Bondy
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Oct 1, 1992·Pharmacology & Toxicology·B Shi, A Haug
Nov 17, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Shunsuke Meshitsuka, David A Aremu
Aug 24, 1999·Archives of Physiology and Biochemistry·G B van der VoetF A de Wolff
Dec 1, 1996·Kidney International·T H IttelH G Sieberth
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Feb 13, 2010·Plant Signaling & Behavior·Frantisek Baluska
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Aug 7, 2007·Journal of Inorganic Biochemistry·Paula P Gonçalves, Virgília S Silva

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