Alveolar and airway sites of nitric oxide inflammation in treated asthma

American Journal of Respiratory and Critical Care Medicine
A F GelbN Zamel

Abstract

The goal of this study was to identify airway and alveolar site(s) of inflammation using exhaled nitric oxide (NO) as a marker in treated patients with asthma, including response to oral corticosteroids, and correlate these sites with expiratory airflow limitation. In 53 (24 male) patients with asthma, age 43 +/- 23 years (mean +/- SD) and all on inhaled corticosteroids, post 180 microg aerosolized albuterol, FEV(1) was 74 +/- 23% predicted and FEV(1)/FVC was 68 +/- 11%. Exhaled NO at 100 ml/second was 27 +/- 23 ppb (p < 0.001 compared with normal, 12 +/- 15 ppb). Bronchial NO maximal flux was 2.4 +/- 3.1 nl/second (p < 0.001 compared with normal, 0.85 +/- 0.55). Alveolar NO concentration was 7.0 +/- 7.4 ppb (p = 0.01 compared with the normal value, 3.2 +/- 2.0 ppb). There was no significant correlation between FEV(1) % predicted or lung elastic recoil and NO bronchial flux or alveolar concentration. However, there was a weak but significant correlation between NO bronchial flux and alveolar concentration (Spearman r = 0.50, p < 0.001). In 10 subjects with asthma on inhaled corticosteroids, 5 days of 30 mg prednisone resulted in isolated significant decreases in NO alveolar concentration, from 13 +/- 10 to 4 +/- 4 ppb (p = 0.00...Continue Reading

References

Feb 1, 1993·The American Review of Respiratory Disease·N CarrollA James
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Feb 1, 1996·Chest·A F GelbL Hadjiaghai
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M KraftR J Martin
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·P E SilkoffN Zamel
Aug 4, 1998·Journal of Applied Physiology·N M Tsoukias, S C George
Oct 12, 1999·Journal of Applied Physiology·A P PietropaoliR W Hyde
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·P E SilkoffS Permutt
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A F Gelb, N Zamel
Feb 15, 2001·The New England Journal of Medicine·W W Busse, R F Lemanske
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·L LehtimäkiE Moilanen
Nov 22, 2001·The European Respiratory Journal·L LehtimäkiE Moilanen
Oct 23, 2002·Journal of Applied Physiology·Hye-Won Shin, Steven C George
Oct 23, 2002·Journal of Applied Physiology·Alain Van MuylemManuel Paiva
Nov 5, 2002·The European Respiratory Journal·L LehtimäkiE Moilanen
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Donald N R PaynePeter K Jeffery
Jan 30, 2003·Thorax·F L M Ricciardolo
Mar 29, 2003·The European Respiratory Journal·S A KharitonovP J Barnes
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Jacob K SontUNKNOWN Asthma Management Project University of Leiden Study Group
Jul 11, 2003·Chest·Henry A JenkinsJoseph D Spahn
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Angelo BarbatoMarina Saetta
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Andrew D SmithD Robin Taylor
Feb 10, 2004·Journal of Applied Physiology·Steven C GeorgePhilip E Silkoff
May 4, 2004·Journal of Applied Physiology·Hye-Won ShinSteven C George

❮ Previous
Next ❯

Citations

Jun 18, 2011·Archivos de bronconeumología·María J Álvarez Puebla, Francisco García Río
Feb 24, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter A WilliamsonBrian J Lipworth
Nov 29, 2007·Current Opinion in Pulmonary Medicine·Arthur F GelbAnita Krishnan
May 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daiki KobayashiKazuto Hirata
Jan 23, 2010·Journal of Applied Physiology·David A ShelleySteven C George
Oct 13, 2010·Respiration; International Review of Thoracic Diseases·Hisako MatsumotoMichiaki Mishima
Mar 26, 2005·American Journal of Respiratory and Critical Care Medicine·Leonardo FabbriEdward Abraham
Jan 30, 2009·Chronic Respiratory Disease·G W RodwayJ M Sethi
Apr 30, 2010·Respiratory Research·James L PuckettSteven C George
Feb 3, 2011·Chest·Maarten van den BergeDirkje S Postma
Aug 14, 2010·Chest·Arthur F GelbSreelakshmi Shakkottai
May 4, 2013·The Journal of Allergy and Clinical Immunology·Nicola ScichiloneVincenzo Bellia
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hitoshi NakajiMichiaki Mishima
Oct 13, 2012·Respiratory Physiology & Neurobiology·Alain Van MuylemAlain Michils
Apr 14, 2010·Respiratory Physiology & Neurobiology·Yannick KerckxAlain Van Muylem
Feb 6, 2010·The Journal of Allergy and Clinical Immunology·Sylvia VerbanckWalter Vincken
Nov 27, 2007·La Presse médicale·Gilles GarciaAlain Didier
May 11, 2011·European Journal of Clinical Investigation·Andrei MalinovschiGerhard Wikström
Aug 18, 2012·The Clinical Respiratory Journal·Dora LudviksdottirAndrei Malinovschi
Nov 19, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Charlotte M H H T RobroeksQuirijn Jöbsis
Jan 20, 2007·Respiratory Medicine·Susan C FoleyPaul McLoughlin
Aug 23, 2011·Respiratory Medicine·Bruno MahutChristophe Delclaux
Feb 14, 2014·The Journal of Allergy and Clinical Immunology·Amaryllis HaccuriaAlain Van Muylem
Nov 23, 2018·Expert Opinion on Drug Delivery·P Worth LongestMichael Hindle
Sep 6, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Daniel MenziesBrian J Lipworth
Jan 26, 2008·Journal of Applied Physiology·Yannick KerckxAlain Van Muylem
Jun 21, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zsófia LázárAndrás Bikov
Mar 22, 2008·Journal of Applied Physiology·Vinod SureshSteven C George
Sep 1, 2008·Journal of Breath Research·Philip Silkoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.