PMID: 7336374Dec 1, 1981Paper

Alveolar development after ligation of left pulmonary artery in newborn pig: clinical relevance to unilateral pulmonary artery

Thorax
S G HaworthM L Fitzpatrick

Abstract

The left pulmonary artery and ductus arteriosus were ligated in 14 pigs at birth. Animals were killed at intervals between two and 24 weeks of age. In all animals, serial chest radiographs were taken. In eight animals, nitrogen-13 lung function studies showed normal fractional ventilation in both lungs and continued growth of the small left lung. After death, the fixed inflated volume was determined in each lung an alveolar development was analysed using quantitative morphometric techniques. In the right lung, after operation alveolar size increased considerably and at two weeks was similar to the normal at six months. The normal phase of rapid postnatal alveolar multiplication was delayed from the first to the second month of life. In all animals aged 20-24 weeks alveolar size was almost normal for age and an abnormal increase in alveolar number produced an abnormally large right lung. In the left lung, the alveoli multiplied to achieve a normal alveolar number in all animals sacrificed at 20 and 24 weeks, but the alveoli were abnormally small. Total lung volume was normal in all animals aged 20 and 24 weeks. The structural findings explained the radiographic and radionuclide investigations. The experimental findings are discu...Continue Reading

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Citations

Jun 1, 1996·Pediatric Pulmonology·P J MerkusP H Quanjer
Apr 13, 2011·General Thoracic and Cardiovascular Surgery·Hiroshi Kubo
Oct 30, 1999·The Annals of Thoracic Surgery·J CaspiE E Fontenot
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Jul 29, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ad hoc Statement Committee, American Thoracic Society
Oct 22, 2002·AJR. American Journal of Roentgenology·Sotiria C ApostolopoulouDimitrios A Kelekis
Jan 15, 2011·Annals of Pediatric Cardiology·Anil Kumar SinghiRaman Krishna Kumar
Jan 19, 2013·Journal of Applied Physiology·Priya RavikumarConnie C W Hsia
Jul 21, 2010·The Journal of Thoracic and Cardiovascular Surgery·Gi Beom KimYong Jin Kim
Sep 1, 1986·The Journal of Surgical Research·G F MurrayJ A Shallal
Mar 31, 2005·The Annals of Thoracic Surgery·Kristin WelchMaully J Shah
Aug 14, 2013·Archives of Cardiovascular Diseases·Peter KruzliakGabriela Kovacova
Sep 29, 2009·The Journal of Thoracic and Cardiovascular Surgery·Ugonna N IhekweazuRaja M Flores
Jul 6, 2018·Journal of the American Heart Association·Konstantinos DimopoulosMichael A Gatzoulis
Oct 9, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hedi RazaviJeffrey A Feinstein
Jul 13, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·C C HsiaH K Hagler
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Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C C HsiaE R Weibel
Oct 17, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ryan PewowarukLuke Lamers

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