PMID: 2496084Mar 1, 1989Paper

Alveolar hyperoxic injury in rabbits receiving exogenous surfactant

Journal of Applied Physiology
G M LoewenS Matalon

Abstract

We have previously demonstrated that instillation of a calf lung surfactant extract (CLSE) in rabbits after exposure to 100% O2 for 64 h mitigates the progression of lung pathology after return to room air (J. Appl. Physiol. 62: 756-761, 1987). In the present study, we investigated whether we could prevent or reduce the onset and development of hyperoxic lung injury by sequential instillations of CLSE during the hyperoxic exposure. Rabbits were exposed to 100% O2. CLSE (125 mg, approximately 170 mumol of phospholipid) was suspended in 10 ml of sterile saline and instilled intratracheally into their lungs, starting at 24 h in O2, a time at which no physiological or biochemical injury was detected, and at 24-h intervals thereafter. Control rabbits breathed 100% O2 and received either equal volumes of saline or no instillations at all. CLSE-instilled rabbits had higher arterial PO2 (Pao2) values throughout the exposure period and survived longer when compared with saline controls [120 +/- 4 vs. 102 +/- 4 (SE) h; n greater than or equal to 10; P less than 0.05]. At 72 h in O2, CLSE-instilled rabbits had significantly higher lavageable alveolar phospholipid levels (12.5 +/- 1.5 vs. 5 +/- 1 mumol/kg) and total lung capacities (41 +/-...Continue Reading

Citations

Aug 19, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Martin LeustikSadis Matalon
Nov 11, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kendra GramImad Y Haddad
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·J Hickman-Davis, S Matalon
Jan 1, 1993·The American Review of Respiratory Disease·J F Lewis, A H Jobe
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·K TokiedaJ A Whitsett
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·R SchermulyD Walmrath
May 1, 1996·Pediatric Pulmonology·D A EvansJ A Whitsett
Feb 23, 2013·Expert Review of Anti-infective Therapy·Iliana BersaniChristian P Speer
Apr 12, 2016·Frontiers in Pediatrics·Daniel ImBarbara Driscoll
Oct 5, 2001·Expert Opinion on Pharmacotherapy·D Willson
May 30, 2002·American Journal of Respiratory Cell and Molecular Biology·Jiali LiRoger G Spragg
Jul 28, 2006·Pediatric Pulmonology·Paul KinniryMelpo Christofidou-Solomidou
Jul 27, 2001·American Journal of Respiratory Cell and Molecular Biology·C W WhiteJ M Shannon
Jun 9, 2007·American Journal of Respiratory Cell and Molecular Biology·Zhengdong WangRobert H Notter
Jul 21, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Min YeeMichael A O'Reilly
Jan 10, 2004·Antioxidants & Redox Signaling·Vijay Boggaram
Aug 17, 1990·Biochimica Et Biophysica Acta·S MatalonB A Freeman
Sep 1, 1996·Clinics in Chest Medicine·A Nahum, R Shapiro
May 27, 2008·Pediatric Clinics of North America·Douglas F WillsonRobert H Notter
Jul 12, 2011·Critical Care Clinics·Krishnan RaghavendranR H Notter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.