Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders

Alcohol
Eileen Bock O'HalloranEllen L Burnham

Abstract

Alcohol use disorders (AUDs) are associated with increased susceptibility to pulmonary diseases, including bacterial pneumonia and acute respiratory distress syndrome (ARDS). Alveolar macrophages (AMs) play a vital role in the clearance of pathogens and regulation of inflammation, but these functions may be impaired in the setting of alcohol exposure. We examined the effect of AUDs on profiles of cytokines, chemokines, and growth factors in human AMs isolated from bronchoalveolar lavage (BAL) samples from 19 AUD subjects and 20 age-, sex-, and smoking-matched control subjects. By multiplex bead array, the lysates of AMs from subjects with AUDs had significant elevation in the cytokine tumor necrosis factor α (TNF-α), as well as chemokine (C-X-C motif) ligand 8 (CXCL8), CXCL10, and chemokine (C-C motif) ligand 5 (CCL5) (p < 0.05). Additionally, a 1.8-fold increase in IL-1β, 2.0-fold increase in IL-6, 2.3-fold increase in interferon gamma (IFN-γ), 1.4-fold increase in CCL3, and a 2.3-fold increase in CCL4 was observed in the AUD group as compared to the control group. We also observed compensatory increases in the anti-inflammatory cytokine IL-1RA (p < 0.05). AUD subjects had 5-fold higher levels of CXCL11 mRNA expression (p < 0....Continue Reading

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Citations

Sep 15, 2016·Alcoholism, Clinical and Experimental Research·Ellen L BurnhamLou Ann S Brown
Sep 19, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S Alex MarshallTodd E Thiele
Oct 30, 2016·Alcohol·Samantha M YeligarLou Ann S Brown
Jul 4, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Murielle GirardPhilippe Nubukpo
Dec 4, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zhilong JiangLei Zhu
Aug 26, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mehdi A FiniEllen L Burnham
Nov 20, 2019·Journal of Clinical Medicine·Shinwan KanyBorna Relja
Jan 21, 2020·Journal of Behavioral Addictions·Mi Ran ChoiDai-Jin Kim
Nov 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeb R Zacharias, Kevin L Legge
Oct 21, 2020·Alcohol·Kristina L BaileyTodd A Wyatt

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