Alveolar Macrophage Polarisation in Lung Cancer

Lung Cancer International
Saleh A AlmatroodiD S Pouniotis

Abstract

The role of alveolar macrophages in lung cancer is multifaceted and conflicting. Alveolar macrophage secretion of proinflammatory cytokines has been found to enhance antitumour functions, cytostasis (inhibition of tumour growth), and cytotoxicity (macrophage-mediated killing). In contrast, protumour functions of alveolar macrophages in lung cancer have also been indicated. Inhibition of antitumour function via secretion of the anti-inflammatory cytokine IL-10 as well as reduced secretion of proinflammatory cytokines and reduction of mannose receptor expression on alveolar macrophages may contribute to lung cancer progression and metastasis. Alveolar macrophages have also been found to contribute to angiogenesis and tumour growth via the secretion of IL-8 and VEGF. This paper reviews the evidence for a dual role of alveolar macrophages in lung cancer progression.

References

Dec 1, 1991·The Journal of Experimental Medicine·C BogdanC Nathan
Nov 14, 1997·Cancer Immunology, Immunotherapy : CII·M C AhnD P Braun
Feb 17, 1998·Virchows Archiv : an International Journal of Pathology·E TolnayK M Müller
Oct 30, 1999·Respiratory Medicine·H YanagawaS Sone
Mar 27, 2001·Experimental and Molecular Pathology·M FathiP Camner
Nov 8, 2001·European Journal of Pharmacology·G FolkertsF P Nijkamp
Mar 16, 2002·European Journal of Clinical Investigation·N Barthelemy-BrichantJ M Deneufbourg
Nov 5, 2002·Critical Reviews in Oncology/hematology·A H KlimpT Daemen
Feb 18, 2003·Scandinavian Journal of Immunology·D MatanićF Milevoj-Ribić
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Mar 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Haifeng M WuClay B Marsh
Apr 2, 2005·The European Respiratory Journal·K NagaiM Nishimura
Jun 18, 2005·Memórias do Instituto Oswaldo Cruz·Soazig NénanClaude P Bertrand
Dec 24, 2005·The Journal of Biological Chemistry·Dawn M FlahertySara L Hinde
Jan 18, 2006·Clinical and Experimental Immunology·D S PouniotisC F McDonald
Jun 17, 2006·Cancer Research·A McGarry HoughtonSteven D Shapiro
Dec 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jose Sullivan Lopez-GonzalezManuel Meneses-Flores
Jul 17, 2007·American Journal of Respiratory Cell and Molecular Biology·Sandra HodgePaul N Reynolds
Jan 8, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Neelam AzadVal Vallyathan
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhra K BiswasClaire E Lewis
Jun 21, 2008·Respiratory Physiology & Neurobiology·Sophie FéréolDaniel Isabey
Mar 10, 2009·Toxicology and Applied Pharmacology·Navneet K DhillonAmy O'Brien-Ladner
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renat ShaykhievRonald G Crystal
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani

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Citations

Jul 19, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pengcheng ChenXiao-Ping Zhong
Jun 7, 2020·Cancers·Maria Joana CatarataRui Medeiros
Apr 29, 2015·Expert Opinion on Drug Delivery·Wing-Hin LeePaul M Young
Oct 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying LiYing Chang
Mar 28, 2020·Genes & Diseases·Andrew N LaneTeresa W-M Fan
Nov 17, 2020·Frontiers in Oncology·Irina LarionovaJulia Kzhyshkowska
Nov 13, 2020·Frontiers in Pharmacology·Devinder ToorHridayesh Prakash
Sep 16, 2021·Melanoma Research·Magda FonsecaPedro Coelho

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
bronchoalveolar lavage

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