Alveolar macrophages from sheep naturally infected by visna-maedi virus contribute to IL-8 production in the lung

Veterinary Immunology and Immunopathology
I LegasteloisG Cordier

Abstract

Sheep naturally infected by visna-maedi virus often develop a chronic interstitial lung disease characterized by an alveolitis comprising lymphocytes, neutrophils and macrophages. The alpha chemokine interleukin-8 (IL-8) was detected in cell free bronchoalveolar lavage fluid from naturally infected animals, confirmed by RT-PCR, presenting typical lesions of maedi and elevated total alveolar cell counts. No detectable IL-8 was found in the fluid obtained from uninfected animals. IL-8 concentration in alveolar fluid is correlated with alveolar neutrophil counts. Bronchoalveolar lavage cells from infected animals were found to contain a large amount of IL-8 mRNA and may contribute to IL-8 production. In situ hybridization showed that macrophages were the predominant cell type expressing IL-8 mRNA. Sustained production of IL-8 by alveolar macrophages during visna-maedi infection could suffice for neutrophil attraction to the alveoli, and may contribute to the development of lesions.

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Citations

Apr 16, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Amaia LarruskainBegoña M Jugo
Nov 15, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S PaltrinieriP Sartorelli
Nov 30, 2007·Journal of Virology·Tom N McNeillyGordon D Harkiss
May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·I LegasteloisG Cordier
Aug 12, 1999·Clinical and Experimental Immunology·G EntricanJ Brown
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Naiara AbendañoBegoña M Jugo

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