Alveolar pressure and airway resistance during maximal and submaximal respiratory efforts

The American Review of Respiratory Disease
T K AldrichD J Prezant


A digital computing technique was used to extract continuous calculations of average alveolar pressure and airway resistance from body plethysmographic measurements during forced inspiratory and expiratory vital capacity maneuvers and tidal breathing in human subjects. Derived alveolar pressures were similar to those obtained using an interrupter technique (linear regression slope, 0.99 +/- 0.02; r = 0.98) and by comparison with esophageal pressure measurements. Studies in normal subjects revealed a characteristic pattern of increasing airway resistance throughout the expiratory phases of maximal and submaximal respiratory maneuvers, with maximal resistance of 33 to 110 cm H2O/L/s at low lung volumes during forced vital capacities. In contrast, inspiratory resistance remained low and constant throughout maximal and submaximal inspiratory maneuvers. Patients with COPD showed substantially higher inspiratory and expiratory resistances. In three patients with flow-volume loops suggestive of variable extrathoracic upper airway obstruction, measurements of alveolar pressure and airway resistance made it clear that two of the patients had upper airway obstruction, whereas the other was exerting an inadequate effort. We conclude that ...Continue Reading


Mar 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R BrownE R McFadden
Jul 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J StocksS Godfrey
Jan 1, 1987·Respiration; International Review of Thoracic Diseases·J VergeretH Guenard
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Jan 1, 1963·The Journal of Clinical Investigation·R E HYATT, R E WILCOX
Jul 1, 1964·Journal of Applied Physiology·M J JAEGER, A B OTIS

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Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Luis Puente-Maestu, William W Stringer
Apr 1, 1993·The American Review of Respiratory Disease·T K AldrichS M Shapiro

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