Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): radiographic observations

Journal of Clinical Periodontology
Knut N LeknesUlf M E Wikesjö

Abstract

The objective of this study was to radiographically evaluate the potential of a purpose-designed titanium porous-oxide implant surface coated with recombinant human bone morphogenetic protein-7 (rhBMP-7), also known as recombinant human osteogenic protein-1 (rhOP-1), to stimulate alveolar ridge augmentation. Six young-adult Hound Labrador mongrel dogs were used. Three 10 mm titanium oral implants per jaw quadrant were placed 5 mm into the alveolar ridge in the posterior mandible following surgical extraction of the pre-molar teeth and reduction of the alveolar ridge leaving 5 mm of the implants in a supra-alveolar position. The implants had been coated with rhBMP-7 at 1.5 or 3.0 mg/ml and were randomized to contralateral jaw quadrants using a split-mouth design. The mucoperiosteal flaps were advanced, adapted, and sutured to submerge the implants. Radiographic registrations were made immediately post-surgery (baseline), and at weeks 4 and 8 (end of study). rhBMP-7-coated implants exhibited robust radiographic bone formation. At 8 weeks, bone formation averaged 4.4 and 4.2 mm for implants coated with rhBMP-7 at 1.5 and 3.0 mg/ml, respectively. There were no significant differences between the rhBMP-7 concentrations at any observ...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S CunninghamA H Reddi
Oct 1, 1992·Current Opinion in Cell Biology·A H Reddi
Jun 1, 1992·Molecular Reproduction and Development·J M Wozney
Nov 12, 1965·Science·M R Urist
Oct 1, 1994·Current Opinion in Genetics & Development·A H Reddi
Dec 1, 1996·Acta Orthopaedica Scandinavica·G HerrW Küsswetter
Jul 11, 2000·Pharmaceutical Research·J E BabenseeA G Mikos
Feb 13, 2001·The American Journal of Medicine·C J HawkeyUNKNOWN Sardinia NSAID meeting
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Nov 2, 2001·Nature·P Bianco, P G Robey
Jan 3, 1959·Lancet·G F WILGRAM, W J TAYLOR
May 31, 2006·Neurosurgical Focus·I H Kalfas
Sep 13, 2006·Journal of Clinical Periodontology·Ulf M E WikesjöJan Hall
Apr 24, 2007·Journal of Clinical Periodontology·Jan HallUlf M E Wikesjö
Feb 14, 2008·Journal of Clinical Periodontology·Cristiano SusinUlf M E Wikesjö

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Citations

Nov 2, 2013·The Journal of Oral Implantology·Rosa-María Díaz-SánchezDaniel Torres-Lagares
Nov 10, 2020·BioMed Research International·Paras AhmadMartin J Stoddart

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