Alveolar soft part sarcoma of the uterine corpus. Report of two cases and review of the literature

Pathology, Research and Practice
K RadigA Roessner

Abstract

Alveolar soft-part sarcoma (ASPS) is a rare tumor of uncertain histogenesis, mainly localized in the extremities and less frequently found in the head, neck and trunk. The present report describes two cases of ASPS localized in the uterus. In general, this entity is very rarely encountered in the female genital tract. Including the two cases presented here, 27 patients have been described in the literature. Whereas the prognosis for ASPS in soft tissues is usually poor (most of the patients died of lung metastases), those localized in the female genital tract are associated with a much better survival. This could be explained by the fact that their diameter seldom exceeds 5 cm, the size which is regarded as being the critical prognostic limit. Histologically, both tumors showed the same characteristics as known for ASPS in other localizations: organoid or nest-like arrangement of tumor cells; rounded or polygonal cells with cytoplasm of varying density; thin-walled, sinusoidal vascular spaces between tumor cell nests. Immunohistochemically, we found positivity for desmin and, to a lesser extent, for vimentin. Cytokeratin was negative, which is important in differential diagnosis to other rare uterine neoplasias like clear cell ...Continue Reading

Citations

Jun 13, 2008·Archives of Gynecology and Obstetrics·Saketh GuntupalliDiane C Bodurka
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P ReichardtB Dörken
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G P Nielsen, R H Young
Mar 23, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Andres A RomaJohn R Goldblum
Jun 12, 2009·World Journal of Surgical Oncology·Mohammed N BaniHani, Abdel Rahman A Al Manasra
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Satomi KasashimaMasaki Inoue
Jun 24, 2008·Fetal and Pediatric Pathology·Pawini KhannaEnid Gilbert-Barness
Apr 23, 2009·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
Apr 4, 2008·Archives of Pathology & Laboratory Medicine·Gemma Toledo, Esther Oliva

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