PMID: 8964731Mar 1, 1996Paper

Alveolar surface area-to-lung volume ratio in oleic acid-induced pulmonary edema

Journal of Applied Physiology
S SuzukiJ P Butler

Abstract

It is unknown how the in vivo alveolar surface area-to-volume ratio (S/V) changes in low-pressure pulmonary edema. Here, the S/V is the area of the air-tissue interface per unit total volume (air plus tissue). We hypothesized that in oleic acid (OA)-induced edema inactivation of the pulmonary surfactant may increase surface tension and decrease the S/V at any given lung volume. OA (0.04 mg/kg) was intravenously injected into dogs. We measured the in vivo S/V (equivalent to the inverse of optical mean free path by light-scattering stereology and the pressure-volume (PV) curve 60-90 min after OA administration. OA administration decreased the lung volume at each transpulmonary pressure and increased the wet-to-dry weight ratio. The S/V decreased after OA administration (optical mean free path increased). The air-filled PV curves shifted downward after OA, but the saline-filled PV curves after OA administration did not differ significantly from control saline-filled curves. The difference in transpulmonary pressure between air- and saline-filled PV curves (an index of the magnitude of surface tension) was increased in OA-induced pulmonary edema. This study suggests that in OA-induced pulmonary edema the alveolar surface tension in...Continue Reading

Citations

Jun 22, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carrie E Perlman, You Wu
Jun 27, 2000·NMR in Biomedicine·R W MairR L Walsworth
May 14, 2003·Journal of Physics. Condensed Matter : an Institute of Physics Journal·J P ButlerS Patz

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