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ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile

PloS One

Aug 23, 2018

Steven E KauderHong I Wan

Abstract

CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune functions. CD47-SIRPα signaling has also been ...read more

Mentioned in this Paper

Study
Tumor Cells, Uncertain Whether Benign or Malignant
Immune Response
Monoclonal antibodies, antineoplastic
Biochemical Pathway
Animal Cancer Model
T-Lymphocyte
Immune Effector Cell
Antigen-Presenting Cells
Neoplastic Cell
3
35
Paper Details
References
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  • References61
  • Citations3
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© 2020 Meta ULC. All rights reserved

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile

PloS One

Aug 23, 2018

Steven E KauderHong I Wan

PMID: 30133535

DOI: 10.1371/journal.pone.0201832

Abstract

CD47 is a widely expressed cell surface protein that functions as an immune checkpoint in cancer. When expressed by tumor cells, CD47 can bind SIRPα on myeloid cells, leading to suppression of tumor cell phagocytosis and other innate immune functions. CD47-SIRPα signaling has also been ...read more

Mentioned in this Paper

Study
Tumor Cells, Uncertain Whether Benign or Malignant
Immune Response
Monoclonal antibodies, antineoplastic
Biochemical Pathway
Animal Cancer Model
T-Lymphocyte
Immune Effector Cell
Antigen-Presenting Cells
Neoplastic Cell
3
35

Feeds With Similar Papers

Co-operation in Effector Responses

Co-operation of immune cells in both innate and adaptive immunity is essential in mounting an appropriate immune effector cell response. Discover the latest research on Co-operation of Effector Responses here.

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Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Current Opinion in Oncology

Targeting CD47 as a cancer therapeutic strategy: the cutaneous T-cell lymphoma experience

Current Opinion in OncologyJuly 12, 2018
Alecia S FolkesChristiane Querfeld
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Activation of phagocytosis by immune checkpoint blockade

Frontiers of MedicineAugust 1, 2018
Chia-Wei LiMien-Chie Hung
Paper Details
References
  • References61
  • Citations3
12345...
  • References61
  • Citations3
1

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