PMID: 9555019May 16, 1998Paper

Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia

Brain Research. Molecular Brain Research
H TanimukaiM Takeda

Abstract

To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia.

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Citations

Mar 3, 2007·Experimental Brain Research·Helena R WattsPeter J B Anderson
Dec 13, 2000·Brain Research. Brain Research Reviews·J C de la Torre, G B Stefano
Jun 27, 2000·Neurobiology of Aging·R N Kalaria
Jun 27, 2000·Neurobiology of Aging·T KudoM Takeda
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Mar 5, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Dec 3, 2014·Pharmacology & Therapeutics·Yi-Lin ChengDong-Gyu Jo
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Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ryszard PlutaMirosław Jabłoński
Dec 19, 2014·Brain Pathology·Seth Love, J Scott Miners
Jan 7, 2015·Neuropathology and Applied Neurobiology·Lindsey I SinclairSeth Love
Jan 31, 2002·Molecular and Cellular Neurosciences·Amir GamlielReuven Stein
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Oct 7, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jun 24, 2006·Neurochemical Research·Phil Hyu LeeKyoon Huh
Mar 9, 2021·Frontiers in Aging Neuroscience·Ryszard PlutaStanisław J Czuczwar
Jul 14, 2004·Brain Research. Molecular Brain Research·Hitoshi TanimukaiKhalid Iqbal

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