Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

FEBS Letters
G DengC W Cotman

Abstract

Presenilin-2 is a gene of unknown function recently identified based upon linkage with some forms of familial Alzheimer's disease. To investigate potential effects of PS-2 on cell viability, rat pheochromocytoma (PC12) cells were stably transfected with cDNA constructs encoding either full-length human PS-2 or, for comparison, mouse Bcl-X(L). Overexpression of PS-2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide. In contrast, Bcl-X(L) overexpression significantly reduced cell death induced by these stimuli. These results suggest that one function of PS-2 may involve modulation of cell viability.

References

Oct 1, 1995·Experimental Neurology·J Y KohD W Choi
Feb 1, 1995·Molecular Neurobiology·C W Cotman, A J Anderson
Jan 1, 1994·Journal of Neurochemistry·R R RatanJ M Baraban
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D T LooC W Cotman

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Citations

Sep 14, 2001·Biochemical and Biophysical Research Communications·J SunJ Gu
Nov 24, 2006·Archives of Pharmacal Research·Hong Nga NguyenJin Tae Hong
Oct 11, 2005·Archives of Pharmacal Research·Hong Nga NguyenJin Tae Hong
Feb 13, 2001·Neurobiology of Aging·R L Neve
Dec 22, 2000·Neurobiology of Aging·S M JanickiM J Monteiro
Jan 19, 2000·Progress in Neurobiology·J C VickersG McCormack
Feb 12, 2000·Progress in Neurobiology·C CzechL Pradier
Oct 1, 1998·Neuroscience Letters·L LindenboimR Stein
Feb 7, 1998·Current Opinion in Neurobiology·T W Kim, R E Tanzi
Jun 26, 2003·The International Journal of Biochemistry & Cell Biology·Yan LingNoor Kalsheker
Jun 11, 1999·Clinical Genetics·M NishimuraP H St George-Hyslop
Aug 7, 1998·Neuroreport·A M GormanS Ceccatelli
Jun 9, 2000·Annual Review of Neuroscience·D NijhawanX Wang
Apr 22, 2003·Annual Review of Neuroscience·Nancy M Bonini, Mark E Fortini
Mar 25, 2004·Lancet Neurology·Xiongwei ZhuMark A Smith
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cristine Alves da CostaMarc P Mattson
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q GuoM P Mattson
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaB Wolozin
Sep 1, 2011·Translational Stroke Research·Patricia AyalaPatricia D Hurn
Sep 17, 2004·The International Journal of Neuroscience·Dae Y HwangJung S Cho
Jul 1, 1997·Reviews in the Neurosciences·M DragunowR L Faull
Jul 31, 1998·Reviews in the Neurosciences·P L McGeerE G McGeer
Apr 10, 2007·Biochemical and Biophysical Research Communications·Hong Nga NguyenJin Tae Hong
Aug 11, 2000·Microscopy Research and Technique·E Van UdenE Masliah
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Nov 10, 2018·Journal of Alzheimer's Disease : JAD·Haowei JiangMorgan Newman
Apr 11, 2006·The Journal of Biological Chemistry·Chuanxi CaiJianjie Ma

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