Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging

Radiology
S MacKayMichael W Weiner

Abstract

To determine the association between H-1 magnetic resonance (MR) spectroscopic imaging and MR imaging differences in subjects with Alzheimer disease (AD) or subcortical ischemic vascular dementia (SIVD) versus control subjects and if both studies combined enable discrimination of AD from control subjects better than either study alone. Measures were obtained in nine AD, eight SIVD, and 11 control subjects with MR imaging segmentation software. Statistically significantly lower N-acetylaspartate/choline-containing metabolites (Cho) and higher Cho/creatine-containing metabolites in posterior mesial gray matter in AD versus control subjects were independent of MR imagining differences. Combined measures allowed correct classification of AD and control subjects, but none of the MR measures allowed accurate discrimination between AD and SIVD subjects. Between-group differences in tissue-type contributions to H-1 MR spectroscopic imaging voxels must be accounted for when reporting H-1 MR spectroscopic imaging data in AD, SIVD, and control subjects. Combined studies allowed more accurate discrimination between AD and control subjects than either study alone.

References

Jan 1, 1992·Magnetic Resonance Imaging·A A MaudsleyM W Weiner
Apr 1, 1992·Journal of the American Geriatrics Society·J KawamuraS Weathers
Apr 15, 1991·Biological Psychiatry·W M McDonaldA Heyman
Feb 1, 1990·Archives of Neurology·M KobariM Ichijo
Jul 1, 1989·Journal of Computer Assisted Tomography·K O Lim, A Pfefferbaum
Jun 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T J DoyleP A Narayana
Jan 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G TedeschiJ R Alger
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·A F LeuchterT F Newton
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A MoatsB D Ross
Feb 1, 1993·Surgical Neurology·A ShiinoJ Handa
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J KawamuraS Weathers
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·V Di SclafaniG Fein

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Citations

Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J O'NeillM W Weiner
Dec 12, 2007·Journal of Digital Imaging·Akmal YounisNigel John
Sep 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A T DuM W Weiner
Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Kejal Kantarci, Clifford R Jack
Jul 22, 2004·Neurological Research·Randall S Jones, Adam D Waldman
Mar 23, 2001·Acta Neurologica Scandinavica. Supplementum·J G ChenP M Doraiswamy
May 1, 2008·The British Journal of Radiology·K Kantarci
Feb 4, 2003·Radiology·Jeffrey R PetrellaP Murali Doraiswamy
Apr 7, 1999·Neurobiology of Aging·W E KlunkJ W Pettegrew
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ilan HalperinSilvia A Mandel
Aug 11, 2007·Journal of Clinical and Experimental Neuropsychology·H Randall GriffithDaniel C Marson
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Wang, S J Li
Sep 24, 2009·Metabolomics : Official Journal of the Metabolomic Society·Ahmet T BaykalHong Li
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·M R EstilaeiD J Meyerhoff
Nov 15, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gioacchino TedeschiSossio Cirillo
Sep 16, 2005·Expert Review of Neurotherapeutics·Kejal Kantarci
Jun 21, 1997·Annals of the New York Academy of Sciences·N SchuffM W Weiner
Jan 31, 2006·Neuroimaging Clinics of North America·Brian J SoherH Cecil Charles
Feb 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X P ZhuN Schuff
Mar 13, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Xiaqing XuanXiangyang Gong
Mar 26, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kejal Kantarci
Feb 19, 2005·Neurobiology of Aging·A J RossH Brodaty
Aug 4, 1998·IEEE Transactions on Medical Imaging·B H BrinkmannR A Robb
Jul 25, 2006·Neurobiology of Aging·Kejal KantarciClifford R Jack
May 4, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Susanne G MuellerLaurel Beckett
Jan 29, 2014·Neurobiology of Aging·Jonathan Graff-RadfordKejal Kantarci
Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W J ChuH P Hetherington
Jan 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonJ W Pan
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L L WaldP F Renshaw
May 23, 1998·NMR in Biomedicine·H P HetheringtonB R Newcomer
Mar 17, 2016·American Journal of Alzheimer's Disease and Other Dementias·Shuang-Qing ChenZhong Zhao
Mar 9, 2018·Annals of Neurology·Nasim Sheikh-BahaeiJonathan H Gillard
Aug 16, 2016·Reviews in the Neurosciences·Golrokh MirzaeiHojjat Adeli

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