Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain

Radiology
N SchuffM W Weiner

Abstract

To replicate previous hydrogen-1 magnetic resonance (MR) spectroscopic imaging findings of metabolic abnormalities in patients with Alzheimer disease (AD), to verify that metabolic abnormalities are not an artifact of structural variations measured at MR imaging, to determine whether metabolic changes correlate with dementia severity, and to test whether MR imaging and MR spectroscopic imaging findings together improve ability to differentiate AD. MR spectroscopic imaging and MR imaging were performed in 28 patients with AD and 22 healthy elderly subjects. Spectroscopic imaging data were coregistered with MR imaging segmentation data to obtain volume-corrected metabolite concentrations. Consistent with previous results, N-acetyl aspartate (NAA) levels were statistically significantly reduced in frontal and posterior mesial cortex of AD patients, presumably due to neuronal loss. NAA level reductions were independent of structural variations measured at MR imaging and, in parietal mesial cortex, were correlated mildly with dementia severity. Spectroscopic imaging findings of NAA level combined with MR imaging measures did not improve discrimination power for AD relative to that of MR imaging alone. Reduced NAA levels in frontopar...Continue Reading

References

Jan 1, 1992·Magnetic Resonance Imaging·A A MaudsleyM W Weiner
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·D L Birken, W H Oldendorf
Aug 1, 1981·Annals of Neurology·R D TerryD S Horoupian
Sep 1, 1995·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·W BlockH H Schild
Nov 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A A MaudsleyM W Weiner
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A MoatsB D Ross
Jan 1, 1993·Journal of Computer Assisted Tomography·S PosseC T Moonen
Jul 1, 1993·Radiology·J H DuynC T Moonen
Nov 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N De StefanoD L Arnold
Jan 17, 1996·Annals of the New York Academy of Sciences·W J Jagust
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Jan 1, 1996·Annual Review of Neuroscience·W J Strittmatter, A D Roses
Mar 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K O Lim, D M Spielman

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Citations

Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J O'NeillM W Weiner
Oct 31, 2002·Journal of the International Neuropsychological Society : JINS·Kejal KantarciClifford R Jack
Sep 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A T DuM W Weiner
Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Apr 20, 2014·AJNR. American Journal of Neuroradiology·F Gao, P B Barker
Mar 23, 2001·Acta Neurologica Scandinavica. Supplementum·J G ChenP M Doraiswamy
May 1, 2008·The British Journal of Radiology·K Kantarci
Jun 19, 2001·NMR in Biomedicine·H in 't ZandtA Heerschap
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph O'NeillMichael W Weiner
Dec 13, 2006·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Peter GarrardAdam D Waldman
Feb 9, 2012·Dementia and Geriatric Cognitive Disorders·Andrea Silveira de SouzaCássio M C Bottino
Jul 26, 2005·Topics in Magnetic Resonance Imaging : TMRI·António J Bastos LeiteFrederik Barkhof
Feb 17, 2000·Current Opinion in Neurology·B G Jenkins, E Kraft
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A HorskáP B Barker
Aug 10, 2013·Neuroimaging Clinics of North America·Kejal Kantarci
Nov 4, 2004·NMR in Biomedicine·John F Schenck, Earl A Zimmerman
Oct 31, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J ModregoM Sarasa
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Hui WangJin-Tai Yu
Nov 3, 2012·Neurobiology of Aging·Natalie M ZahrAdolf Pfefferbaum
Feb 20, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu G KhomenkoD S Susin
Aug 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan I Kirov, Assaf Tal
May 4, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Susanne G MuellerLaurel Beckett
Nov 14, 2002·Brain : a Journal of Neurology·Karen J FergusonJoanna M Wardlaw
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Martijn C de WildeJohn W Sijben
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·J W PanH P Hetherington
Dec 6, 2001·Arquivos de neuro-psiquiatria·E EngelhardtA C Oliveira
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch

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