Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
H Diana RosasNicole Schupf

Abstract

Virtually all adults with Down syndrome (DS) develop Alzheimer's disease (AD)-associated neuropathology by the age of 40, with risk for dementia increasing from the early 50s. White matter (WM) pathology has been reported in sporadic AD, including early demyelination, microglial activation, loss of oligodendrocytes and reactive astrocytes but has not been extensively studied in the at-risk DS population. Fifty-six adults with DS (35 cognitively stable adults, 11 with mild cognitive impairment, 10 with dementia) underwent diffusion-weighted magnetic resonance imaging (MRI), amyloid imaging, and had assessments of cognition and functional abilities using tasks appropriate for persons with intellectual disability. Early changes in late-myelinating and relative sparing of early-myelinating pathways, consistent with the retrogenesis model proposed for sporadic AD, were associated with AD-related cognitive deficits and with regional amyloid deposition. Our findings suggest that quantification of WM changes in DS could provide a promising and clinically relevant biomarker for AD clinical onset and progression.

References

May 1, 1992·Journal of the American Geriatrics Society·M Albert, C Cohen
Aug 1, 1989·Archives of Neurology·F Lai, R S Williams
Jun 1, 1989·The New England Journal of Medicine·B RumbleC L Masters
Jul 1, 1993·Journal of Clinical and Experimental Neuropsychology·B A WilsonT Bryant
Apr 1, 1997·Journal of Intellectual Disability Research : JIDR·E H AylwardA Dalton
Jan 23, 1999·Biological Psychiatry·L D Selemon, P S Goldman-Rakic
Feb 15, 2002·Archives of Neurology·Stefan J TeipelHarald Hampel
Oct 2, 2002·Journal of Intellectual Disability Research : JIDR·D A DevennyS J Krinsky-McHale
Mar 6, 2004·American Journal of Mental Retardation : AJMR·Wayne SilvermanRobert Ryan
Sep 16, 2005·International Journal of Geriatric Psychiatry·Martin SjöbeckElisabet Englund
May 25, 2007·Brain : a Journal of Neurology·John M RingmanGeorge Bartzokis
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Jul 4, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·George BartzokisJim Mintz
Dec 17, 2008·Annals of the New York Academy of Sciences·H Diana RosasSteven M Hersch
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Jan 18, 2012·NeuroImage·Bruce Fischl
Oct 30, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Benjamin L HandenWilliam E Klunk
Mar 4, 2014·Neurobiology of Aging·David PowellElizabeth Head
Jul 6, 2014·Brain : a Journal of Neurology·Sigan L HartleyBradley T Christian
Jun 1, 2015·Neuroscience·S-H LeeUNKNOWN Alzheimer’s disease Neuroimaging Initiative (ADNI)
Feb 23, 2017·Journal of Alzheimer's Disease : JAD·Raquel FenollRafael de la Torre
Jun 10, 2017·Neuroscience·Enrica CavedoUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Sep 22, 2018·Brain : a Journal of Neurology·Miguel Ángel Araque CaballeroMichael Ewers
Feb 25, 2019·NeuroImage. Clinical·Xin ZhangUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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