Alzheimer's Dementia due to Suspected CTE from Subconcussive Head Impact

Case Reports in Neurological Medicine
Shauna H Yuan, Sonya G Wang

Abstract

Chronic traumatic encephalopathy (CTE) has been receiving increasing attention due to press coverage of professional football players. The devastating sequelae of CTE compel us to aim for early diagnosis and treatment. However, by current standards, CTE is challenging to diagnose. Clear clinical diagnostic criteria for CTE have not been established. Only recently, pathological diagnostic criteria have been recognized, but postmortem diagnosis is too late. Reliable biomarkers are not available. By imaging criteria, cavum septum pellucidum has been the only consistent identifiable MRI finding. Because of the imprecise nature of diagnosis based on clinical suspicion, physicians must become cognizant of the broad spectrum of presentations of CTE. With this awareness, appropriate workup can be initiated. CTE can present with early symptoms of emotional changes or late symptoms with memory decline and dementia. Here we present an unusual case of a patient with Alzheimer's disease secondary to suspected CTE that stems from subconcussive head impacts presenting with severe memory and MRI changes. Clinicians should be aware of this presentation and consider CTE in their differential diagnoses while undergoing workup of memory disorders.

References

Aug 1, 1973·Psychological Medicine·J A CorsellisD Freeman-Browne
Oct 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·P M KempR J Pethybridge
Aug 1, 2006·Journal of Magnetic Resonance Imaging : JMRI·Michael H ChappellRichard Watts
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Ann C McKeeRobert A Stern
Aug 19, 2010·Nuclear Medicine Communications·Frank Anthony ProvenzanoMasanori Ichise
Nov 9, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Robert A SternAnn C McKee
Nov 15, 2012·JAMA : the Journal of the American Medical Association·Inga K KoerteMartha E Shenton
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W SmallJorge R Barrio
Mar 13, 2013·Nature Reviews. Neurology·Barry D Jordan
Aug 27, 2013·Journal of Neurosurgery·Julian E BailesThomas Talavage
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jorge R BarrioVladimir Kepe
Apr 24, 2015·Brain Pathology·Inga K KoerteMartha E Shenton
Apr 24, 2015·Brain Pathology·Ann C McKeeVictor E Alvarez
May 7, 2015·Acta Neuropathologica·Thor D SteinAnn C McKee
Feb 22, 2017·Molecular Neurodegeneration·Laure Saint-AubertAgneta Nordberg
Jul 26, 2017·JAMA : the Journal of the American Medical Association·Jesse MezAnn C McKee

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Sep 25, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Mustafa Karaağaç, Melek Karakurt Eryılmaz

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