Alzheimer's disease - not an exaggeration of healthy aging.

Indian Journal of Psychological Medicine
Krishnendu GhoshGreg Haggerty

Abstract

The world population is becoming older now. The boom of the elderly population comes from public health efforts to improve living conditions and prevent disease, and from improved medical interventions. People more than 65-year-old who are representing 12.9% of the population now is expected to grow to be 19% of the population by 2030. Very few numbers of diseases will have such socioeconomic burden on society in the newer world. Although Alzheimer's disease (AD) has been studied very well recently, still its exact etiopathogenesis is unknown. Currently there are no available tests for the definitive diagnosis of AD. So the clinical diagnosis of AD remains a diagnosis of exclusion. This limits the potential for early intervention. The difference between normal degenerative processes of brain and preclinical changes of AD is a gray zone and there is no particular way to distinguish between the two. Now several modalities like functional magnetic resonance imaging (fMRI), positron emission tomography (PET) scan, electrophysiological tests and cerebrospinal fluid (CSF) biomarkers for tauopathy and Aβ have shown to be promising in the development of early diagnostic tools for neurodegenerative changes and help us to differentiate b...Continue Reading

References

Jan 1, 1977·Archives of Neurology·P L McGeerJ S Suzuki
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jan 1, 1992·Journal of Gerontology·K O LimA Pfefferbaum
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jul 4, 1985·The New England Journal of Medicine·P T FrancisG K Wilcock
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·D G Morgan
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F YoshiiR Duara
Jun 1, 1987·Annals of Neurology·R D TerryL A Hansen
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Feb 1, 1983·Journal of Neurochemistry·N R SimsA N Davison
Dec 1, 1982·Journal of Neurochemistry·J A SeversonC E Finch
Jul 1, 1996·Neurobiology of Aging·K L DoubleG A Broe
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Dec 31, 1997·Journal of Neuropathology and Experimental Neurology·R E MrakD I Graham
May 5, 1998·Neurology·C R GuttmannM S Albert
Jul 17, 1998·Annals of Neurology·N D VolkowN Pappas
Apr 21, 1999·Brain Research. Brain Research Reviews·W Klimesch
Jun 22, 1999·Journal of Neuropathology and Experimental Neurology·K HatanpääS I Rapoport
Apr 19, 2000·Journal of Cognitive Neuroscience·P A Reuter-LorenzR A Koeppe
Nov 9, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C HuangV Jelic
May 7, 2002·The Australian and New Zealand Journal of Psychiatry·H Christensen
Oct 10, 2002·Biological Psychiatry·Alberto FernándezTomás Ortiz
Dec 4, 2003·Journal of Experimental Psychology. General·Timothy A SalthouseDiane E Berish
Jan 6, 2004·Cerebral Cortex·David J MaddenScott A Huettel
Jan 24, 2004·Psychological Science·Marcia K JohnsonErich J Greene
Apr 27, 2004·Neuroreport·Kristy A NielsonElliot A Stein
May 5, 2004·Neurobiology of Aging·Corina PennanenHilkka Soininen
Jul 28, 2004·NeuroImage·Paul M ThompsonArthur W Toga

❮ Previous
Next ❯

Citations

Apr 14, 2015·CNS Neuroscience & Therapeutics·Chun-Chao HuangChing-Po Lin
Mar 22, 2014·Scandinavian Journal of Psychology·P-L Lee
Jul 3, 2013·American Journal of Alzheimer's Disease and Other Dementias·Pai-Lin LeeChiao-Li Wang
Sep 18, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Md Sahab UddinMst Marium Begum
Feb 11, 2020·Brain : a Journal of Neurology·Alexa Pichet BinetteUNKNOWN PREVENT-AD Research Group
Aug 15, 2018·Journal of Alzheimer's Disease : JAD·Daniel G AmenNoble George
Aug 22, 2018·Frontiers in Aging Neuroscience·Elena D OsipovaAlla B Salmina
May 28, 2021·Brain Connectivity·Aina Frau-PascualIman Aganj

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.