Alzheimer's disease Aβ42 peptide induces an increase in Na,K-ATPase glutathionylation

Doklady. Biochemistry and Biophysics
V A LakuninaAlexander A Makarov

Abstract

We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ42), an Alzheimer's disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,K-ATPase, it is proposed to use reducing agents, which promote normalization of the redox status of cells and deglutathionylation of the protein.

References

Nov 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I PetrushankoA Bogdanova
Nov 29, 2005·Cell Death and Differentiation·S AkterinA Cedazo-Minguez
Mar 28, 2007·Journal of Neuroscience Research·Shelley F NewmanD Allan Butterfield
Apr 26, 2012·Antioxidants & Redox Signaling·Erin M G Allen, John J Mieyal
Jul 17, 2012·The Journal of Biological Chemistry·Irina Yu PetrushankoAnna Bogdanova
Jul 24, 2012·Biochimica Et Biophysica Acta·Victor M VitvitskyRuma Banerjee
Sep 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Sergej YakushevAnna Bogdanova
Dec 4, 2012·Nutrients·William M JohnsonJohn J Mieyal
Jun 15, 2016·Scientific Reports·Irina Yu PetrushankoAlexander A Makarov

❮ Previous
Next ❯

Citations

Apr 1, 2018·Arhiv za higijenu rada i toksikologiju·Kristina Dominko, Domagoj Đikić

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Related Papers

Clinical Chemistry
Daniela GiustariniRanieri Rossi
The Journal of Biological Chemistry
J B Lingrel, T Kuntzweiler
© 2022 Meta ULC. All rights reserved