PMID: 2126477Sep 10, 1990Paper

Alzheimer's disease amyloid precursor protein is present in the myelin sheath of central nervous system in rat

Brain Research
K Ikeda, M Tomonaga

Abstract

By using polyclonal antibodies to C- and N-terminal portions of beta-amyloid precursor protein (APP), we immunohistochemically examined postnatal and adult rat brains. Immunoreactivity was observed in myelin of nerve fibers in myelination and of mature myelinated fibers, as well as in various brain cells. In trigeminal nerve roots, the immunoreactivity was observed in central myelin but not in peripheral myelin. The results strongly suggest that APP is a component of central myelin in rat.

References

Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R PalmertS G Younkin
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeT Oltersdorf
Nov 1, 1973·Journal of Neurochemistry·R H QuarlesR O Brady
Sep 1, 1984·Journal of Neuroimmunology·C LinningtonP L Woodhams
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Feb 1, 1982·Journal of Computer Assisted Tomography·L M ZatzA J Ahumada
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Peggy S EisJames E Dahlberg

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Citations

May 1, 1992·Journal of Neuroscience Research·M MizuguchiS U Kim
Feb 1, 1992·Neuropathology and Applied Neurobiology·F CoriaJ Ghiso
Mar 18, 2003·Journal of Neuropathology and Experimental Neurology·R Ross ReichardDavid Dolinak
Sep 25, 2009·Neurobiology of Aging·George Bartzokis

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