Alzheimer's disease and brain development: common molecular pathways

Frontiers in Bioscience : a Journal and Virtual Library
K Jordan-Sciutto, R Bowser

Abstract

Research on the causes and treatments of Alzheimer's disease (AD) has led investigators down numerous avenues. Although many models have been proposed, no single model of AD satisfactorily accounts for all neuropathologic findings as well as the requirement of aging for disease onset. The mechanisms of disease progression are equally unclear. We hypothesize that alternative gene expression during AD plays a critical role in disease progression. Numerous developmentally regulated genes and cell cycle proteins have been shown to be re-expressed or activated during AD. These proteins include transcription factors, members of the cell cycle regulatory machinery, and programmed cell death genes. Such proteins play an important role during brain development and would likely exert powerful effects if re-expressed in the adult brain. We propose that the re-expression or activation of developmentally regulated genes define molecular mechanisms active both during brain development and in AD.

Citations

Oct 6, 2007·Journal of Neuropathology and Experimental Neurology·Charleen T ChuKelly L Jordan-Sciutto
Dec 26, 2007·MCN. the American Journal of Maternal Child Nursing·Ananda P DasanayakeNok Chhun
Aug 10, 2000·The American Journal of Pathology·K L Jordan-SciuttoC A Wiley
Oct 29, 1998·Neuroscience Letters·R Bowser, S Reilly

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