PMID: 16627937Apr 22, 2006Paper

Alzheimer's disease and head circumference

Journal of Alzheimer's Disease : JAD
Patricio S EspinosaCharles D Smith

Abstract

Larger brains may contain more neurons and synaptic connections, providing a greater reserve against cognitive decline in Alzheimer's disease (AD). Larger head circumference (HC) may therefore be associated with later detection and diagnosis of AD. We investigated HC in nondemented individuals and AD patients using cross-sectional and prospective analyses. The cross sectional analysis compared mean HC between 592 AD patients and 459 nondemented controls. Prospective analysis was based on the same initially normal controls who were followed longitudinally for conversion to dementia. Diagnosis of AD was made by neurologists using NINDS-ADRDA criteria. When compared to AD patients, controls had a significantly larger mean HC by 0.58 cm in men and by 0.31 cm in women, but these differences were no longer significant after adjustment for age and years of education. HC varied inversely with age and directly with years of education but did not vary with presence/absence of dementia in first-degree relatives or with apolipoprotein-E (ApoE) genotype. In the prospective analysis, the hazard ratio for time to conversion to AD was not significant for HC when adjusted for age at entry, ApoE allele status, family history of dementia, gender,...Continue Reading

Citations

Jan 7, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Rebecca J MelroseDan Mungas
Nov 26, 2010·Expert Review of Neurotherapeutics·Jennifer L Whitwell
Jun 27, 2008·Alzheimer Disease and Associated Disorders·James A MortimerWilliam R Markesbery
Nov 12, 2020·Curēus·Patricio H Espinosa Del PozoNicolas F Andrade

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