Alzheimer's Disease and ncRNAs

Advances in Experimental Medicine and Biology
Rotem MaozHermona Soreq

Abstract

Alzheimer's disease is a devastating neurodegenerative disorder affecting a significant portion of the world's rapidly growing aging population. In spite of its prevalence, the etiology of the disease is still poorly understood, and effective therapy is all but unavailable. Over the past decade, noncoding RNA, including microRNA (miRNA), has emerged as a major class of regulatory molecules involved in virtually all physiological and disease states. The specificity provided by miRNA sequence complementarity, together with the ability of these molecules to regulate complex networks of genes, has made them exciting novel targets for therapeutic agents. In this chapter, we review recent progress on understanding the role of noncoding RNA in Alzheimer's disease (AD). The majority of available work has focused on miRNA, and we review the many studies implicating specific miRNAs in the development of the disease. More recently, several studies have tied other RNA classes to the disorder, including long noncoding RNA, circular RNA, and Y RNAs, and we review this fascinating field as well. Finally, we explore the potential promise of these findings for future therapeutic applications.

Citations

Jan 4, 2018·DNA and Cell Biology·Cheng GuYi Zhang
Jun 12, 2018·Neurodegenerative Disease Management·Andrea Stoccoro, Fabio Coppedè
Jan 18, 2019·Bioscience, Biotechnology, and Biochemistry·Xinhua WangHengfang Liu
Apr 25, 2020·FEBS Letters·Nimrod Madrer, Hermona Soreq
Sep 7, 2018·Experimental and Therapeutic Medicine·Wenting ZhangMinwu Xia
Nov 15, 2019·Journal of Toxicology and Environmental Health. Part a·Ming ZhangZhi-Ying Zhao
Mar 19, 2019·Frontiers in Genetics·Mengli WangBeisha Tang
Jul 12, 2018·Journal of Alzheimer's Disease : JAD·Morena ZussoPietro Giusti
Jun 2, 2020·Frontiers in Cellular Neuroscience·Ximena Paez-ColasanteEva L Feldman
Jan 29, 2020·Current Neuropharmacology·Vivek Kumar SharmaThakur Gurjeet Singh
Jan 29, 2021·Translational Psychiatry·Andrea VergalloUNKNOWN Alzheimer Precision Medicine Initiative (APMI)
Apr 27, 2021·ACS Chemical Neuroscience·Liang HeMeilin Lu
Sep 14, 2020·Mechanisms of Ageing and Development·Adriane D HenriquesUNKNOWN Brazilian Aging Brain Study Group

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