Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.

CNS & Neurological Disorders Drug Targets
Medha PriyadarshiniGhazi A Damanhouri

Abstract

Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two debilitating health disorders afflicting millions worldwide. Recent research has revealed similarities between AD and T2DM. Both these protein conformational disorders are associated with obesity, insulin resistance, inflammation and endoplasmic reticulum stress, en-route initiation and/or stage aggravation. In this mini review we have tried to summarize studies describing obesity, insulin resistance and glucocorticoid imbalance as common patho-mechanisms in T2DM and AD. A reduction in tyrosine hydroxylase (TH) in the brain has been found to occur in Parkinson's disease (PD). AD, T2DM and PD share common risk factors like depression. Thus, whether TH is involved in the 'state of cognitive depression' that is the hallmark of AD and often accompanies PD and T2DM is also explored.

Citations

May 12, 2015·Biochimica Et Biophysica Acta·Magnus HoleAurora Martinez
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Giulio TaglialatelaLuca Cicalese
Oct 23, 2012·Physiology & Behavior·Elinor L SullivanKatherine A Chamlou
Jan 7, 2015·Saudi Journal of Biological Sciences·Gohar MushtaqMohammad A Kamal
Feb 25, 2014·Journal of Young Pharmacists : JYP·Md Rezaul IslamSajib Chakraborty
Oct 12, 2013·Journal of the American Society of Nephrology : JASN·Peter StenvinkelT Alp Ikizler
Apr 24, 2020·The European Journal of Neuroscience·Pasquale PiconeDomenico Nuzzo
Apr 14, 2016·Biomedical Reports·David Calderón GuzmánNorma Osnaya Brizuela
Mar 27, 2020·Saudi Journal of Biological Sciences·Richard L JayarajRami Beiram
Apr 30, 2021·Chemical Research in Toxicology·Qi YanBeate R Ritz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.