Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes.

Metabolic Brain Disease
Maja MustapicDorotea Muck-Seler

Abstract

Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-α gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-α gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-α gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Sep 1, 1983·The Journal of Clinical Investigation·M S Brown, J L Goldstein
Jun 26, 1995·Biochemical and Biophysical Research Communications·A HamannJ S Flier
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E J SijbrandsA H Smelt
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Sep 5, 2003·Experimental Gerontology·Claude Messier
Jan 30, 2004·Diabetes·Juliette JansonPeter C Butler
Jun 3, 2006·Atherosclerosis·Susan J MurdochUNKNOWN DCCT/EDIC Research Group
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F I V ErreraM R Passos-Bueno
Sep 9, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Shuk-Woon MaVincent T F Yeung
Oct 28, 2008·Neurobiology of Aging·Judith MiklossyPatrick L McGeer
Apr 24, 2009·Journal of Alzheimer's Disease : JAD·Angelika Bierhaus, Peter P Nawroth
Aug 15, 2009·Neuron·Jungsu KimDavid M Holtzman
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Daniel P Perl
Sep 8, 2010·Trends in Molecular Medicine·Valérie LeducJudes Poirier
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Jul 17, 2013·International Journal of Molecular Sciences·Li LinQing Tian
Sep 24, 2013·Molecular Biology Reports·Madhukar SaxenaMonisha Banerjee
Oct 21, 2016·Geriatrics & Gerontology International·Melda BozluolcayDildar Konukoglu
Mar 3, 2018·Journal of Neuroscience Research·B S Alghamdi
Jul 15, 2017·Annals of Human Biology·Grażyna AdlerAlmira Hadzovic-Dzuvo
Oct 6, 2016·Diabetes Care·Nicholette D Palmer AllredBarry I Freedman

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