Alzheimer's Disease and Vascular Aging: JACC Focus Seminar.

Journal of the American College of Cardiology
Marta Cortes-Canteli, Costantino Iadecola

Abstract

Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibility that they may have a pathogenic role. This review provides an appraisal of the alterations in cerebral and systemic vasculature, the heart, and hemostasis that occur in Alzheimer's disease and their relationships to cognitive impairment. Although the molecular pathogenesis of these alterations remains to be defined, amyloid-β is a likely contributor in the brain as in the heart. Collectively, the evidence suggests that vascular pathology is a likely pathogenic contributor to age-related dementia, including Alzheimer's disease, inextricably linked to disease onset and progression. Consequently, the contribution of vascular factors should be considered in preventive, diagnostic, and therapeutic approaches to address one of the major health challenges of our time.

Citations

Jun 25, 2020·Current Cardiology Reports·Gianlorenzo DanieleFederica Del Monte
May 1, 2020·Nature·Makoto Ishii, Costantino Iadecola
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Klaus Grossmann
Dec 15, 2020·American Journal of Alzheimer's Disease and Other Dementias·Joseph S D'Arrigo
Feb 5, 2021·Mechanisms of Ageing and Development·Jacopo SabbatinelliFabiola Olivieri
Feb 20, 2021·Journal of the American College of Cardiology·Marta Cortes-CanteliValentin Fuster
Feb 20, 2021·Journal of the American College of Cardiology·Valentin Fuster
Mar 26, 2021·BioMed Research International·Chen-Geng LiuPei-Chang Wang
Mar 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Min-Soo KimWon Kyung Jeon
Apr 16, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cecilia BjörnfotAnders Wåhlin
May 6, 2021·International Journal of Molecular Sciences·Klaus Grossmann
Jun 16, 2021·Nature Reviews. Nephrology·Zoltan UngvariAnna Csiszar
Jul 3, 2021·Frontiers in Aging Neuroscience·Sanghamitra Bandyopadhyay
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Magdalena I ToleaJames E Galvin
Jul 16, 2021·Frontiers in Cell and Developmental Biology·Hui XuYou-Shuo Liu
Jul 29, 2021·Circulation·Michael H CriquiUNKNOWN American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biol
Aug 7, 2021·Nature Neuroscience·Samantha Schaeffer, Costantino Iadecola
Aug 15, 2021·Experimental Gerontology·Daniel H CraigheadDouglas R Seals
Aug 21, 2021·Acta Neurologica Scandinavica·Gorica MaricJelena Drulovic
Jul 10, 2021·Journal of the American College of Cardiology·Borja IbanezValentín Fuster
Aug 24, 2021·Cells & Development·Marie OuarnéCláudio Areias Franco
Nov 11, 2021·Journal of Biochemical and Molecular Toxicology·Komal JabeenMuhammad Sajid Hamid Akash

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