Alzheimer's disease, dementia, and stem cell therapy

Stem Cell Research & Therapy
Thomas Duncan, Michael Valenzuela

Abstract

Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT01297218
NCT01696591
NCT02054208
NCT02912169
NCT02833792
NCT01547689
NCT02600130
NCT02672306
NCT02899091

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