Alzheimer's disease drug development pipeline: 2020

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Jeffrey L CummingsKate Zhong

Abstract

Alzheimer's disease (AD) is a growing public health concern affecting millions of patients worldwide and costing billions of dollars annually. We review the pipeline of drugs and biologics in clinical trials for the treatment of AD. We use the Common Alzheimer's and Related Dementias Research Ontology (CADRO) to classify treatment targets and mechanisms of action. We review our annual pipeline reports for the past 5 years to provide longitudinal insight into clinical trials and drug development for AD. We reviewed ClinicalTrials.gov as of February 27, 2020, and identified all trials of pharmacologic agents currently being developed for treatment of AD as represented on this widely used U.S. Food and Drug Administration registry. There are 121 agents in clinical trials for the treatment of AD. Twenty-nine agents are in 36 Phase 3 trials, 65 agents are in 73 Phase 2 trials, and 27 agents are in 27 Phase 1 trials. Twelve agents in trials target cognitive enhancement and 12 are intended to treat neuropsychiatric and behavioral symptoms. There are 97 agents in disease modification trials. Compared to the 2019 pipeline, there is an increase in the number of disease-modifying agents targeting pathways other than amyloid or tau. The 20...Continue Reading

References

Aug 25, 2011·Alzheimer's Research & Therapy·Jeffrey CummingsKate Zhong
Jul 4, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lorenzo M RefoloMaria C Carrillo
Nov 6, 2012·Nature Reviews. Drug Discovery·Anne CorbettClive Ballard
Jan 12, 2013·Dementia and Geriatric Cognitive Disorders·Brian S ApplebyJeffrey L Cummings
Sep 26, 2013·Current Topics in Medicinal Chemistry·Brian S Appleby, Jeffrey L Cummings
Jan 15, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Gerard J MarekRobert A Lenz
Feb 20, 2014·JAMA : the Journal of the American Medical Association·Anton P PorsteinssonUNKNOWN CitAD Research Group
Mar 12, 2015·The New England Journal of Medicine·Monique L AndersonRobert M Califf
Sep 24, 2015·JAMA : the Journal of the American Medical Association·Jeffrey L CummingsJoão Siffert
Feb 18, 2016·Alzheimer Disease and Associated Disorders·Jeff SevignyJerome Barakos
Jan 1, 2015·Nature Reviews. Disease Primers·Colin L MastersJeffrey L Cummings
Sep 2, 2016·Nature·Jeff SevignyAlfred Sandrock
Oct 13, 2017·Translational Neurodegeneration·Jeffrey Cummings
Aug 17, 2016·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsGaram Lee
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsKate Zhong
Dec 10, 2017·Alzheimer's Research & Therapy·Susanne OstrowitzkiUNKNOWN SCarlet RoAD Investigators
May 3, 2018·The New England Journal of Medicine·Michael F EganDavid Michelson
Jun 30, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsKate Zhong
Sep 13, 2018·JAMA : the Journal of the American Medical Association·Jennifer Abbasi
Nov 2, 2018·JAMA Neurology·Anirudh Sreekrishnan
Feb 6, 2019·Nature Biotechnology·Chris Morrison
Feb 13, 2019·Advances in Experimental Medicine and Biology·Jeffrey Cummings
Apr 11, 2019·The New England Journal of Medicine·Michael F EganDavid Michelson
Jun 12, 2019·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nathan HerrmannKrista L Lanctôt
Jul 10, 2019·JAMA Neurology·Lon S SchneiderUNKNOWN Alzheimer’s Disease Cooperative Study TCAD Study Group
Jul 25, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsKate Zhong
Oct 8, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Stephan EhrhardtUNKNOWN S-CitAD Research Group
Nov 12, 2019·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·George T GrossbergJeffrey L Cummings
Jan 17, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·W Joseph HerringDavid Michelson
Feb 6, 2020·Drugs·Yahiya Y Syed
Feb 26, 2020·Drugs·Yahiya Y Syed

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Citations

Sep 10, 2020·Journal of Personalized Medicine·Chiara ArgentatiSabata Martino
Aug 19, 2020·Alzheimer's Research & Therapy·Justin BauzonJeffrey Cummings
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Klaus Grossmann
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa PurgatorioCosimo D Altomare
Jan 10, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jalayne J AriasKathryn A Phillips
Feb 8, 2021·Neuromolecular Medicine·Jun Yup LeeAnthony S Don
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeinab Breijyeh, Rafik Karaman
Dec 31, 2020·International Journal of Molecular Sciences·Francesco TavantiMaria Cristina Menziani
Jan 31, 2021·Neurochemistry International·Sarah JarrinEilís Dowd
Dec 22, 2020·Journal of Medicinal Chemistry·Angela De SimoneAndrea Milelli
Dec 22, 2020·Frontiers in Neuroscience·Antonio MunafòGiuseppina Cantarella
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia AlbertiniMaria Laura Bolognesi
Mar 2, 2021·Frontiers in Pharmacology·Satoshi SaitoMasafumi Ihara
Apr 4, 2021·Pharmaceutics·Ana MatoševićTomica Hrenar
Apr 13, 2021·Expert Opinion on Therapeutic Targets·Fabio Coppedè
Apr 9, 2021·Journal of Medicinal Chemistry·Michele RossiMaria Laura Bolognesi
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pedro Cruz-VicenteEugenia Gallardo
Apr 30, 2021·Frontiers in Cellular Neuroscience·Benoit SchneiderJean-Marie Launay
May 13, 2021·Neuropsychiatric Disease and Treatment·Tamas FulopJacek M Witkowski
May 15, 2021·Journal of Medical Economics·Charles MakinDana Goldman
May 25, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Michelle R CampbellAlicia Algeciras-Schimnich
Jan 22, 2021·Physiological Reviews·Camilla Ferrari, Sandro Sorbi
May 28, 2021·Frontiers in Aging Neuroscience·Helena Sophia GleerupAnja Hviid Simonsen
Jun 3, 2021·Cells·Stefania MerighiDavide Ferrari
Jun 3, 2021·International Journal of Molecular Sciences·Mantas ZiaunysVytautas Smirnovas
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anatoly S UrbanEduard V Bocharov
Jun 8, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsKazem Taghva
Jun 8, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsGaram Lee
Jul 3, 2021·Biology·Giulia AbateSimone Tambaro
Jul 3, 2021·Frontiers in Pharmacology·Lydia Giménez-Llort, Björn Johansson

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT04241068
NCT03486938
NCT02547818
NCT03790709
NCT03393520
NCT02446132
NCT03226522
NCT03980730
NCT03887455
NCT03605667

Software Mentioned

TU
CADRO
DIAN

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