Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.

Sleep
V. MutoGilles Vandewalle

Abstract

Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer's disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. We computed whole-genome PRS for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation, and extended sleep opportunity, in a carefully selected homogenous sample of 363 healthy young men (22.1 years ± 2.7) devoid of sleep and cognitive disorders. AD PRS was associated with more slow-wave energy, that is, the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with larger slow-wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness. These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and support the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.

References

Jul 31, 1998·Journal of Sleep Research·M Steriade, F Amzica
Feb 8, 2006·Archives of General Psychiatry·Margaret GatzNancy L Pedersen
Mar 10, 2007·Current Biology : CB·Antoine U ViolaDerk-Jan Dijk
May 10, 2008·The American Journal of Pathology·Jeffrey A FeinKaren Hoppens Gylys
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael B DashGiulio Tononi
Mar 20, 2010·Alzheimer's Research & Therapy·Nilüfer Ertekin-Taner
Oct 29, 2010·Nature·Gonçalo R AbecasisGil A McVean
Dec 21, 2010·Acta Neuropathologica·Heiko Braak, Kelly Del Tredici
Jan 14, 2011·The European Journal of Neuroscience·Julie CarrierDaniel Filipini
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Astrid SydowEva-Maria Mandelkow
May 3, 2011·Nature Neuroscience·Adam W BeroDavid M Holtzman
Dec 16, 2011·Cerebral Cortex·Mert R SabuncuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 9, 2012·Cerebral Cortex·Reto HuberMarcello Massimini
Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam W BeroDavid M Holtzman
Apr 26, 2012·Acta Neuropathologica·Ann Van der JeugdEva-Maria Mandelkow
Jun 7, 2012·Neurobiology of Disease·Xiyun ChaiMartin Citron
Jan 24, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Linn Hege NilsenUrsula Sonnewald
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jerrah K HolthJeffrey L Noebels
Apr 5, 2013·PLoS Genetics·Frank Dudbridge
Feb 19, 2014·The Journal of Experimental Medicine·Kaoru YamadaDavid M Holtzman
Jan 1, 2015·Bioinformatics·Jack EuesdenPaul F O'Reilly
May 27, 2015·Nature Neuroscience·Erik S Musiek, David M Holtzman
Jun 2, 2015·Nature Neuroscience·Bryce A ManderMatthew P Walker
Jun 19, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kristel SleegersUNKNOWN BELNEU consortium
Aug 19, 2015·Brain : a Journal of Neurology·Heiko Braak, Kelly Del Tredici
Oct 23, 2015·Brain : a Journal of Neurology·Valentina Escott-PriceJulie Williams
Nov 22, 2015·Journal of Neuroscience Methods·Dorothée Coppieters 't WallantChristophe Phillips
Jan 13, 2016·Alzheimer Disease and Associated Disorders·Jessica R MardenM Maria Glymour
Feb 21, 2016·Trends in Cognitive Sciences·Mara Mather, Carolyn W Harley
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier

❮ Previous
Next ❯

Citations

Oct 20, 2021·PLoS Computational Biology·Grégory HammadChristina Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.