Alzheimer's Disease: Genomics and Beyond

International Review of Neurobiology
Fuhai SongHongxing Lei

Abstract

Alzheimer's disease (AD) is a major form of senile dementia. Despite the critical roles of Aβ and tau in AD pathology, drugs targeting Aβ or tau have so far reached limited success. The advent of genomic technologies has made it possible to gain a more complete picture regarding the molecular network underlying the disease progression which may lead to discoveries of novel treatment targets. In this review, we will discuss recent progresses in AD research focusing on genome, transcriptome, epigenome, and related subjects. Advancements have been made in the finding of novel genetic risk factors, new hypothesis for disease mechanism, candidate biomarkers for early diagnosis, and potential drug targets. As an integration effort, we have curated relevant data in a database named AlzBase.

Citations

Mar 20, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Stuart MaudsleyUNKNOWN Brain Health Modeling Initiative (BHMI)
Nov 23, 2018·Neuroscience and Biobehavioral Reviews·Zuo-Teng WangJin-Tai Yu
Mar 9, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Chunrui LiZhiyong Pei

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