PMID: 8596319Mar 2, 1996Paper

Alzheimer's disease in Finnish twins

Lancet
I RaihaL Sourander

Abstract

The genetics of Alzheimer's disease (AD) are obscure. Although most cases are sporadic half the patients with sporadic AD have a positive family history. The mode of genetic transmission and the role of environmental factors are unknown. The purpose of this study was to examine the contribution of genetic factors to the pathogenesis of AD in a twin cohort. The Finnish Twin Cohort consists of all Finnish same-sexed twin pairs born before 1958 with both co-twins alive in 1975. The total number of twin pairs is 13 888, of whom 4307 are monozygotic (MZ) and 9581 ar dizygotic (DZ). These data were linked with the Hospital Discharge Register from 1972 to 1991 to identify twins who had dementia or related disease as a discharge diagnosis. The linkage of the registries yielded a total of 285 twin individuals. The medical records of these twins and their co-twins were reviewed to confirm and classify dementia (AD, vascular dementia, mixed dementia, and other dementia). The incidence, concordance, and age at onset of AD were examined. The incidence of AD was significantly higher in MZ than in DZ twin individuals, with and adjusted MZ/DZ incidence ratio of 1.8 (95% confidence intervals 1.2 to 2.7). In contrast, the incidence of vascular o...Continue Reading

References

Jan 1, 1978·Human Heredity·S SarnaM Koskenvuo
Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Feb 20, 1987·Science·P H St George-HyslopD Drachman
Aug 1, 1988·Neurology·R J MarttilaU K Rinne
Oct 1, 1987·Neurology·E KinnunenK Aho
Jul 1, 1985·Neurology·R SulkavaJ Palo
May 1, 1981·Archives of Neurology·R H CookD B Clark
Feb 18, 1995·BMJ : British Medical Journal·K ChristensenA I Yashin
Sep 18, 1993·Lancet·J PoirierS Gauthier
Feb 1, 1993·Neurology·J C BreitnerM F Folstein
Mar 8, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Jyrki T Kuikka

❮ Previous
Next ❯

Citations

Sep 14, 2011·Archives of Neurology·Thomas S WingoDavid J Cutler
Feb 13, 2001·European Journal of Pharmacology·F Richard, P Amouyel
Apr 6, 1996·Lancet·K ChristensenJ W Vaupel
Dec 10, 2002·Neurobiology of Aging·Stephen R Robinson, Glenda M Bishop
Aug 21, 2003·Neurobiology of Aging·Tarja JärvenpääJuha O Rinne
Dec 22, 1999·Neurobiology of Aging·C B Dobson, R F Itzhaki
Oct 6, 1997·Geriatrics·A M Goate
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I RäihäL Sourander
May 13, 2010·Psychological Medicine·O J BienvenuK S Kendler
Sep 20, 2008·Nature Reviews. Neuroscience·Lars Bertram, Rudolph E Tanzi
Aug 22, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·K ChristensenJ W Vaupel
Apr 8, 1999·Molecular Pathology : MP·L TilleyN Kalsheker
Aug 20, 2005·BMC Microbiology·Suzanne J ShipleyCurtis B Dobson
Oct 19, 2010·International Journal of Alzheimer's Disease·L ChouliarasB P F Rutten
Mar 29, 2014·Oxidative Medicine and Cellular Longevity·Marco Antonio Meraz-RíosVictoria Campos-Peña
Jun 15, 1996·Lancet·I RäihäL Sourander
Jul 10, 2001·Aging : Clinical and Experimental Research·I McDowell
Nov 14, 1997·Tropical Medicine & International Health : TM & IH·M Prince
Feb 3, 2004·Annals of Neurology·Nancy L PedersenBoo Johansson
Nov 26, 2011·The International Journal of Neuroscience·Sanxi AiBeisha Tang
Jul 31, 2007·Neurologic Clinics·Nilüfer Ertekin-Taner
Jun 10, 2000·Journal of Aging and Health·K ChristensenJ W Vaupel
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Apr 17, 1999·American Journal of Medical Genetics·S F PosnerM Gatz
Aug 10, 1999·International Journal of Geriatric Psychiatry·J C Breitner
Apr 24, 2001·The British Journal of Psychiatry. Supplement·B Cooper
Jun 25, 2016·Journal of Alzheimer's Disease : JAD·Hedieh K MohseniWilliam V Prestwich
Jul 17, 2001·Periodontology 2000·P Hodge, B Michalowicz
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Christopher R BeamMargaret Gatz
Nov 21, 2007·Dementia and Geriatric Cognitive Disorders·Jyri J VirtaJuha O Rinne
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Hedieh K Mohseni, David R Chettle
Apr 24, 2020·Neuroscience and Biobehavioral Reviews·Paula Iso-MarkkuIna M Tarkka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved