Alzheimer's disease: many failed trials, so where do we go from here?

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Allison Bethanne ReissMark M Stecker

Abstract

Alzheimer's disease (AD) is a neurodegenerative brain disorder associated with relentlessly progressive cognitive impairment and memory loss. AD pathology proceeds for decades before cognitive deficits become clinically apparent, opening a window for preventative therapy. Imbalance of clearance and buildup of amyloid β and phosphorylated tau proteins in the central nervous system is believed to contribute to AD pathogenesis. However, multiple clinical trials of treatments aimed at averting accumulation of these proteins have yielded little success, and there is still no disease-modifying intervention. Here, we discuss current knowledge of AD pathology and treatment with an emphasis on emerging biomarkers and treatment strategies.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Nov 24, 1999·Molecular and Cellular Neurosciences·I HussainG Christie
Feb 24, 2001·Annals of the New York Academy of Sciences·C A LemereD J Selkoe
Jun 25, 2005·Current Alzheimer Research·Rudi K TannenbergPeter R Dodd
Mar 20, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anders WimoLinus Jönsson
Jan 11, 2011·Molecular Brain·Yun-wu ZhangHuaxi Xu
Feb 22, 2012·Alzheimer Disease and Associated Disorders·Liana G ApostolovaPaul M Thompson
Mar 1, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Allison B Reiss, Iryna Voloshyna
Mar 8, 2012·Psychiatry Investigation·Jee Wook KimIhn-Geun Choi
Mar 20, 2012·Cell·Yadong Huang, Lennart Mucke
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shreaya ChakrobortyGrace E Stutzmann
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Jun 14, 2013·Science Translational Medicine·Rachel PotterRandall J Bateman
Jul 26, 2013·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Semagacestat Study Group
Jul 31, 2013·Neurology·Giovanni B FrisoniUNKNOWN ISTAART's NeuroImaging Professional Interest Area
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Jan 24, 2014·The New England Journal of Medicine·Stephen SallowayUNKNOWN Bapineuzumab 301 and 302 Clinical Trial Investigators
Aug 5, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Suzanne M de la Monte
Jan 6, 2015·Journal of the American College of Radiology : JACR·Franz J WippoldRatham M Subramaniam
Apr 1, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Osama SabriUNKNOWN Florbetaben Phase 3 Study Group
Oct 27, 2015·BMC Public Health·Riccardo E MarioniHelene Jacqmin-Gadda
Dec 9, 2015·Current Neuropharmacology·Jennifer Y Y Szeto, Simon J G Lewis
Feb 2, 2016·Ageing Research Reviews·Lorenzo PiniGiovanni B Frisoni
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier
Mar 26, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bruno DuboisUNKNOWN Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclin
Mar 31, 2016·EMBO Molecular Medicine·Dennis J Selkoe, John Hardy
Jun 15, 2016·Acta Neuropathologica Communications·Val J LoweMelissa E Murray
Dec 28, 2016·Acta Neuropathologica·Eleanor Drummond, Thomas Wisniewski
Mar 21, 2017·Neurobiology of Aging·Niklas MattssonUNKNOWN Geneva Task Force for the Roadmap of Alzheimer's Biomarkers
Jul 20, 2017·Lancet Neurology·Giovanni B FrisoniBengt Winblad
Jul 27, 2017·EMBO Molecular Medicine·Niklas MattssonOskar Hansson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

Pakistan Journal of Biological Sciences : PJBS
Mervat Ibrahim Khairallah, Lobna Abdel Aal Kassem
International Journal of Molecular Sciences
Md Tanvir KabirMohamed M Abdel-Daim
Biochimica Et Biophysica Acta
Jill K MorrisJeffrey M Burns
© 2021 Meta ULC. All rights reserved