'Alzheimer's disease': more data, but are we any more informed?

Current Opinion in Psychiatry
Hans Förstl

Abstract

While we adhere to traditional misconceptions regarding the nature of age-associated neurodegenerative, and vascular and other brain changes, we will not re-design our research projects, and we will not reconsider and improve our pragmatic diagnostic and therapeutic approach. This review focuses (1) on the continuum of cognitive deficits from mild cognitive impairment to manifest dementia, (2) on the spectrum of neurodegenerative, vascular and other cerebral co-morbidity, and (3) on some reversible examples of the rare outliers (limbic encephalitis, Hashimoto encephalopathy) not to be included in the common severity and cerebral co-morbidity spectrum of senile cognitive impairment. We will only be more informed if we accept appropriate concepts and draw the right conclusions. Important new research has not yet filtered into the minds of dementia researchers specializing in 'normal ageing' or 'mild cognitive impairment', 'Alzheimer's disease' or 'dementia with Lewy bodies', tauopathies or synucleopathies, etc.

References

Feb 13, 2003·Archives of Neurology·Ji Y ChongRobert D Utiger
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Steffen Gais, Jan Born
May 29, 2004·Neurobiology of Aging·Diana S Woodruff-PakGary L Wenk
Jun 24, 2004·Dementia and Geriatric Cognitive Disorders·Sascha M C RasquinFrans R J Verhey
Jun 24, 2004·Neurobiology of Aging·Henrike WolfHermann-Josef Gertz
Jun 24, 2004·JAMA : the Journal of the American Medical Association·Mark A EspelandUNKNOWN Women's Health Initiative Memory Study
Aug 18, 2004·Journal of Geriatric Psychiatry and Neurology·Dag AarslandGlenda Halliday
Aug 21, 2004·Psychiatrische Praxis·Peter Günther, Andrea Kopf
Oct 2, 2004·Stroke; a Journal of Cerebral Circulation·Steven M GreenbergEric E Smith
Oct 19, 2004·Neuroscience Letters·Barbara BorroniAlessandro Padovani
Oct 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·S M C RasquinJ Lodder
Nov 13, 2004·Journal of the Neurological Sciences·Malee S FernandoUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Nov 24, 2004·Neurology·V SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Dec 2, 2004·Dementia and Geriatric Cognitive Disorders·Alan ThomasRaj Kalaria
Dec 4, 2004·Learning & Memory·Steffen Gais, Jan Born
Dec 15, 2004·Archives of Neurology·Ben SeltzerUNKNOWN Donepezil "402" Study Group
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Kenneth M LangaEric B Larson
Dec 21, 2004·Journal of the Neurological Sciences·Colin P Doherty
Dec 21, 2004·Journal of the Neurological Sciences·Don J MahadRichard M Ransohoff
Dec 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·C PennanenH Soininen
Jan 27, 2005·American Journal of Epidemiology·Mark A EspelandStephen R Rapp
Jan 29, 2005·Dementia and Geriatric Cognitive Disorders·Samantha GalluzziGiovanni B Frisoni
Feb 9, 2005·Archives of General Psychiatry·Nunzio PomaraJohn J Sidtis
Feb 15, 2005·Brain and Cognition·Elise J LevinoffHoward Chertkow
Mar 4, 2005·Journal of the American Geriatrics Society·Anthony F JormLon R White
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Jane B TornatoreMary E McGann
Mar 10, 2005·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D William MolloyDavid L Lewis
Mar 12, 2005·Journal of the Neurological Sciences·S M C RasquinF R J Verhey
Mar 12, 2005·Journal of the Neurological Sciences·John S MeyerJuebin Huang
Mar 12, 2005·Journal of the Neurological Sciences·Barbara BorroniAlessandro Padovani
Mar 19, 2005·Cerebrovascular Diseases·Sascha RasquinFrans Verhey
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·William R ShankleXijiang Sun
Mar 24, 2005·Dementia and Geriatric Cognitive Disorders·Hiroaki KazuiMasatoshi Takeda
Apr 1, 2005·The American Journal of Psychiatry·Mamoru HashimotoEtsuro Mori
Apr 2, 2005·Dementia and Geriatric Cognitive Disorders·E KalbeK Herholz

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Citations

Mar 12, 2019·Journal of Alzheimer's Disease : JAD·Anika KaczynskiWolfgang Hoffmann
Aug 5, 2017·Scientific Reports·Rustamzhon MelikovSedat Nizamoglu
Oct 22, 2010·Deutsches Ärzteblatt International·Richard Mahlberg

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